在心肺旁路手术后,肠道菌群的变化和对肠道功能的影响在患有心室隔膜缺陷的婴儿中
Qi-Liang Zhang1, Si-Jia Zhou1, Xiu-Hua Chen1
1Department of Cardiac Surgery, Fujian Medical University (Fujian Branch of Shanghai Children's Medical Center), College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China.
Current problems in cardiology
|September 28, 2023
概括
心脏手术 (VSD修复) 后婴儿肠道细菌的变化显示多样性减少和有益的细菌,增加胃肠道问题和恢复时间.
科学领域:
- 微生物学 微生物学
- 儿童心脏病学 儿童心脏病学
- 胃肠病学 胃肠病学
背景情况:
- 心室隔膜缺陷 (VSD) 是一种常见的先天性心脏异常.
- 心肺绕道 (CPB) 手术通常需要进行VSD修复.
- 手术后的胃肠功能障碍是CPB手术后婴儿的一个重大问题.
研究的目的:
- 在CPB手术后调查患有VSD的婴儿肠道菌群的变化.
- 探索这些微生物变化与术后胃肠功能恢复之间的关系.
主要方法:
- 在CPB手术前后,从20名患有VSD的婴儿收集了便样本.
- 16S rRNA测序用于微生物检测和分析.
- 使用统计分析来比较微生物组成,并与临床结果相关联.
主要成果:
- CPB手术导致肠道菌群多样性和物种丰富度显著下降.
- 手术后的肠道菌群显示,菌菌增加,双菌水平降低.
- 较高的Enterococcus和较低的Bifidobacterium水平与胃肠道功能障碍和延长的食恢复有关.
结论:
- CPB手术显著改变婴儿的肠道微生物群,减少有益的细菌和增加潜在的病原体.
- 这些微生物转变与胃肠功能受损和VSD修复后延迟恢复有关.
- 准肠道微生物群可能为接受CPB手术的婴儿提供改善结果的策略.
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