在多囊卵巢综合征中优化维生素D状态:系统性审查和剂量反应元分析
Kelsey M Cochrane1,2, Jeffrey N Bone2,3, Brock A Williams1,2
1Food, Nutrition and Health, Faculty of Land and Food Systems, The University of British Columbia, Vancouver, BC, Canada.
Nutrition reviews
|September 28, 2023
概括
维生素D补充对患有PCOS的女性有好处,但剂量超过3000IU/天显示最小的附加值. 需要对更高剂量进行更多研究,以确定PCOS患者的临床意义.
科学领域:
- 内分泌学 在内分泌学.
- 营养科学 营养科学
- 生殖健康 生殖健康
背景情况:
- 多囊卵巢综合征 (PCOS) 是一种普遍存在的内分泌疾病,影响生殖年龄的女性.
- 维生素D补充正在作为PCOS的补充疗法进行探索.
- 目前关于PCOS维生素D剂量的指导方针缺乏基于证据的共识.
研究的目的:
- 在患有PCOS的女性中对维生素D补充进行剂量反应元分析.
- 为PCOS管理制定基于证据的维生素D补充指南.
主要方法:
- 在 MEDLINE,CINAHL 和 EMBASE 数据库中进行系统搜索,截至 2022 年 11 月.
- 包括八项相关研究,其中包括关于血清25(OH) D水平和维生素D剂量的数据.
- 在剂量反应曲线分析和灵敏度分析中应用受限立方线.
主要成果:
- 观察到维生素D摄入量和血清25(OH) D水平之间存在显著的剂量反应关系 (P < .001).
- 血清25(OH) D水平上升至大约3000IU/天,随后在3000-5000IU/天之间停滞.
- 超过3000IU/天的维生素D剂量的益处似乎很小,剂量>5000IU/天的数据有限.
结论:
- 患有PCOS的女性表现出对维生素D补充剂的反应.
- 超过3000 IU/天的维生素D剂量为PCOS患者提供了有限的额外益处.
- 需要进一步研究以澄清PCOS中较高维生素D摄入量 (>5000 IU/天) 的剂量反应和临床效用.
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