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Updated: Jul 15, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
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通过SET介导的p53表观遗传失调会损害三乙烯诱导的DNA损伤反应

Xiaohu Ren1, Jiawen Ruan2, Xuerao Lan3

  • 1Shenzhen Key Laboratory of Modern Toxicology, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, No 8 Longyuan Road, Nanshan District, Shenzhen 518055, China.

Toxicology letters
|September 28, 2023
PubMed
概括

三乙烯 (TCE) 暴露会损害肝细胞. 通过H3K79me3-p53表观遗传轴,SET蛋白会影响DNA损伤对TCE的反应,从而影响肝毒性.

关键词:
对DNA损伤的反应反应肝细胞毒性 肝细胞毒性在P53中,P53是P53设置 设置 设置在希斯H3K79的三甲基化.三乙烯是一种三乙烯.

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