关于伪连续动脉旋转标记MRI用于肺 perfusion 成像的应用
Joshua S Greer1, Yiming Wang2, Durga Udayakumar3
1Department of Radiology, UT Southwestern Medical Center, Dallas, TX, USA; Department of Pediatrics, UT Southwestern Medical Center, Dallas, TX, USA.
心脏触发的右肺动脉标记与背景抑制有效评估肺 perfusion 使用伪连续的动脉旋转标记MRI. 这种方法尽量减少信号变化,以便在健康志愿者中进行强大的成像.
科学领域:
- 医学成像医学成像
- 心血管和呼吸系统.
- 磁共振成像 (MRI) 是一种磁共振成像技术.
背景情况:
- 肺输液成像对于评估肺部健康至关重要.
- 伪连续动脉旋转标记 (pCASL) MRI提供了一种非侵入性的输液评估方法.
- 优化pCASL技术对于准确的肺 perfusion 量化至关重要.
研究的目的:
- 为了评估和比较不同的伪连续动脉旋转标记 (pCASL) MRI 方法,以有效评估肺 perfusion.
- 确定最优的pCASL技术,最大限度地减少信号变化并提高成像稳定性.
主要方法:
- 在健康志愿者中评估了四种pCASL标签和获取策略.
- 这些方法包括心脏触发的下静脉内腔 (IVC) 标签,心脏触发的IVC标签,心脏触发的右肺动脉 (RPA) 标签,心脏触发的RPA标签,心脏触发的RPA标签和背景抑制 (BGS).
- 使用变化系数 (COV) 评估图像质量,并将最佳方法与交替流量反转恢复 (FAIR) 进行比较.
主要成果:
- 下腔静脉 (IVC) 标签对心率变化敏感.
- 心脏触发的收获改善了信号的一致性,但与背景抑制不兼容.
- 与IVC标记方法相比,用BGS标记心脏触发的RPA显著降低了COV (0.34 ± 0.03).与IVC标记方法相比,使用BGS标记显著降低了COV (0.34 ± 0.03).
- 通过心脏触发的RPA标签和BGS获得的输液值与FAIR.测量的值相似.
结论:
- 使用pCASL-MRI进行肺 perfusion 成像对心脏相位敏感,因此需要方法来减少流动诱导的信号变化.
- 心脏触发的RPA标签与背景抑制相结合,为肺 perfusion 成像提供了强大的和有效的方法.
- 这种优化的pCASL技术可以提供可靠的输液测量,可降低变异性.
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