通过使用原始活性炭产品,从常规和专业的凝血试验中去除直接的口服因子XA抑制剂干扰
Gavin T Buckley1, Ber Murphy2, Niamh Fleming2
1Department of Haematology, Cork University Hospital, Wilton, Cork, Ireland; EOLAS Research Group, Cork University Hospital, Wilton, Cork, Ireland.
Clinica chimica acta; international journal of clinical chemistry
|September 28, 2023
概括
活性炭 (AC) 有效地从血中去除像阿皮克萨班和里瓦罗克萨班这样的直接口服抗凝剂 (DOAC),从而消除测试干扰. 这种方法对Sysmex CS系列分析仪的大多数常规和专用凝血试验的影响最小.
科学领域:
- 临床化学 临床化学
- 血液学 血液学 血液学
- 药理学 药理学是指药理学的学科.
背景情况:
- 直接口服抗凝剂 (DOAC) 广泛用于血栓形成的预防和治疗.
- DOACs显著干扰各种凝血试验,使准确的测试复杂化.
- 开发减轻DOAC干扰的方法对于可靠的实验室诊断至关重要.
研究的目的:
- 调查原始活性炭 (AC) 在最小化DOAC相关干扰方面的有效性.
- 评估AC治疗对常规和专业凝血参数的影响.
- 在Sysmex CS系列分析仪上评估AC的有效性.
主要方法:
- 人类血样本,有或没有变化的DOAC度,用AC处理.
- 在AC治疗前后测量了常规和专业的凝血参数.
- 测试包括在CS系列分析仪上进行激活的部分血栓形成时间 (APTT) 和其他测试.
主要成果:
- 在非抗凝血血中,AC治疗对大多数常规和专用凝血参数的影响最小.
- 在一些基于APTT的试验中,在AC治疗后观察到具有临床意义的延长.
- 在受影响的试验中,AC有效地吸附了apixaban和rivaroxaban,解决了DOAC相关的干扰.
结论:
- 原始活性炭有效地从人体血中吸附阿皮克萨班和里瓦罗克萨班.
- 在CS系列分析仪上的大多数凝血参数上,AC处理解决了与DOAC相关的干扰.
- 这种方法提供了一种有前途的策略,可以提高DOAC患者的凝血测试准确度.
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