系统性免疫炎症指数和心力衰竭之间的关联:来自NHANES 1999-2018年的证据
Huizhen Zheng1, Ziwei Yin1, Xi Luo1
1Department of Cardiology, The First Affiliated Hospital of Hunan University of Chinese Medicine, Changsha 410007, China; College of Chinese Medicine, Hunan University of Chinese Medicine, Changsha 410208, China.
International journal of cardiology
|September 28, 2023
概括
系统性免疫炎症指数 (SII) 的升高与心力衰竭 (HF) 的更高风险有关. 这种新的炎症标志物显示出与HF患病率的非线性关联,需要进一步调查.
科学领域:
- 心血管医学 心血管医学
- 免疫学 免疫学 免疫学
- 公共卫生 公共卫生
背景情况:
- 心力衰竭 (HF) 与炎症过程密切相关.
- 系统性免疫炎症指数 (SII) 是一种新发现的炎症标志物.
研究的目的:
- 研究系统性免疫炎症指数 (SII) 和心力衰竭 (HF) 之间的关联.
- 探索SII在HF中的非线性关系和潜在影响因素.
主要方法:
- 利用国家健康和营养检查调查数据 (1998-2018) 来自48,155名成年人.
- 计算的SII是 (血小板数 × 中性粒细胞数/淋巴细胞数).
- 采用多重物流回归,子组分析,平滑曲线拟合和值效应分析.
主要成果:
- 患有最高SII的参与者表现出HF患病率增加32%的风险 (OR = 1.32;95% CI,1.06-1.65).
- SII和HF之间的关联是非线性的,转折点为1104.78 (1000细胞/μl).
- 在SII和特定子组之间没有发现显著的相互作用.
结论:
- 升高的SII水平与心力衰竭的风险增加密切相关.
- SII和HF之间的关系是非线性的.
- 需要进一步的前性研究来验证这些发现并探索潜在的机制.
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