大脑功能连接组定义了一个跨诊断维度,由前青少年的认知功能和精神病理学共享
Xiang Xiao1, Christopher Hammond2, Betty Jo Salmeron1
1Neuroimaging Research Branch, National Institute on Drug Abuse, National Institutes of Health, Baltimore, Maryland.
Biological psychiatry
|September 28, 2023
概括
年轻人的新型大脑网络模式将认知功能与精神病理联系起来,预测精神疾病的发展. 这种高度可遗传的连接组测量方法提供了对青少年心理健康的个人差异和弹性方面的见解.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 发展心理学 发展心理学
背景情况:
- 认知功能和一般心理病理是与精神障碍相关的关键维度.
- 这些维度与影响精神疾病风险的特定大脑网络之间的联系尚不清楚.
研究的目的:
- 为了确定大脑功能连接体和青少年行为评估之间的潜在的维度关联.
- 调查精神疾病中确定的大脑网络模式的预测能力和遗传性.
主要方法:
- 从青少年大脑认知发展 (ABCD) 研究中对11,875名青少年 (9-10岁) 的纵向研究.
- 机器学习使用正统相关性分析将静止状态的功能连接体与认知和精神病理学的措施联系起来.
- 使用2年随访数据评估预测有效性,使用双胞胎数据评估遗传性.
主要成果:
- 确定了一个强大的潜在功能连接组模式,与多域行为评估密切相关 (交叉验证 ρ = 0.56-0.73).
- 这种模式具有高度遗传性 (h2 = 74.42%) 并显示了与精神疾病负担的剂量反应关系.
- 连接组模式预测了在2年内跨疾病的诊断过渡.
结论:
- 研究结果表明,基于连接体的跨诊断测量是精神疾病发展的个人差异的基础.
- 这一指标可能反映了与适应能力或青春期早期心理健康状况风险相关的大脑网络.
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