重用alagebrium治疗糖尿病足:对AGE/NFκB/NOX1信号传递的影响
Afnan Harb1, Mahmoud H Elbatreek1, Ahmed Elshahat2
1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
European journal of pharmacology
|September 28, 2023
概括
阿拉基是一种先进的糖化最终产品 (AGE) - 交叉链断裂器,在老鼠中显著加快了糖尿病足 (DFU) 的愈合. 这种AGE-crosslink断路器改善了感官功能和步态,表明了DFU管理的潜力.
科学领域:
- 生物医学研究的研究.
- 伤口愈合研究 伤口愈合研究
- 糖尿病并发症研究研究
背景情况:
- 糖尿病足 (DFU) 是糖尿病的严重并发症,导致残疾.
- 目前对DFU的治疗方法不足以控制其进展.
- 先进的糖化终产品 (AGE) -交叉链断路器正在研究治疗潜力.
研究的目的:
- 为了研究alagebrium的治疗影响,一个AGE-crosslink断裂器,在糖尿病足 (DFU) 治愈.
- 评估用于DFU治疗的alagebrium的全身和局部管理.
- 评估alagebrium对与DFU相关的生物化学标记物和组织表达物的影响.
主要方法:
- 糖尿病Wistar大鼠使用STZ诱导,随后是足部伤口诱导.
- 阿拉格被口服 (10毫克/公斤) 或局部作为膜形成凝.
- 评估了伤口愈合,感官功能,步态,生化标志物 (HbA1c,AGE,MDA,NOX1) 和组织表达 (NF-κB, iNOS,TNF-α,VEGF,EGF).
主要成果:
- 系统和局部alagebrium加速糖尿病伤口愈合和改善组织学结果.
- 在糖尿病大鼠中,alagebrium增强了感官功能和步态.
- 治疗减少了AGE,MDA,NOX1,NF-κB,iNOS和TNF-α,同时增加了VEGF和EGF水平.
结论:
- 阿拉格里在加速糖尿病足 (DFU) 愈合方面表现出显著的潜力.
- 重新定位alagebrium可能为患有DFU的糖尿病患者提供改善的临床结果.
- 系统和局部两种形式的alagebrium都显示出对DFU管理的希望.
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