延长时间的莱特莫维尔在异性造血干细胞移植中
Breanna Hinman1, James Cox1, Godsfavour Umoru1
1Houston Methodist Hospital, 6565 Fannin St., Houston, TX 77054, USA.
Transplant immunology
|September 28, 2023
概括
在异性干细胞移植后,延长的勒特莫维尔预防可能会减少细胞巨型病毒 (CMV) 的重新激活. 这项研究发现,在接受100天以上预防的CMV阳性患者中,CMV复激活率较低.
科学领域:
- 血液学 血液学 血液学
- 传染性疾病 传染性疾病
- 移植医学 移植医学 移植医学
背景情况:
- 细胞巨乳病毒 (CMV) 感染在异构造血型细胞移植 (HCT) 后带来重大风险.
- 目前的莱特莫维尔预防指南建议在HCT后100天内在CMV阳性接受者中使用.
- 延长100天以上的勒特莫维尔预防的益处仍然不清楚.
研究的目的:
- 评估延长时间的莱特莫维尔预防在预防CMV复激活方面的有效性.
- 为了比较标准 (≤100天) 和延长 (>100天) 莱特莫维尔预防在CMV阳性HCT接受者的CMV复活率.
主要方法:
- 87名CMV-阳性全原性HCT接受者的回顾性图表审查.
- 患者在移植后0-28天之间开始服用莱特莫维尔.
- 标准和扩展的莱特莫维尔预防组之间的CMV复激活率的比较.
主要成果:
- 与标准持续时间 (中位数78天,28%) 相比,延长的勒托莫维尔预防 (中位数132天) 与较低的CMV复激活率 (19%) 相关.
- 在标准持续时间组中发生了一例CMV肺炎病例.
- 在第200天的全因死亡率在各组之间是相似的.
结论:
- 延长超过100天的莱特莫维尔预防可能会降低CMV病毒在CMV病毒阳性HCT接受者的CMV再激活.
- 进一步的研究可能会支持更长的预防时间,以减轻CMV并发症.
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