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识别与免疫检查点相关的lncRNA生物标志物,用于免疫治疗反应和癌症的预后

Yue Gao¹, Xinyue Wang¹, Longlong Dong¹

¹College of Bioinformatics Science and Technology, Harbin Medical University, Harbin, 150081, China.

Scientific data

|September 28, 2023

概括

这项研究确定了新的长非编码RNA (lncRNA) 和免疫检查点合作调节对 (ICPaLncCRPs),可以预测癌症预后和对免疫检查点抑制剂 (ICI) 的反应. 这些发现揭示了癌症免疫治疗的潜在新生物标志物.

科学领域:

在瘤学瘤学.
免疫学免疫学免疫学
基因组学就是基因组学.
生物信息学是一种生物信息学.

背景情况:

长非编码RNAs (lncRNAs) 在瘤免疫中发挥作用,但它们的特定功能和免疫检查点抑制剂 (ICI) 反应的预测潜力在很大程度上尚未被探索.
只有有限数量的lncRNAs被描述为它们参与癌症免疫和预测ICI疗效.

研究的目的:

为确定癌症和免疫背景特定的ICP和IncRNA合作调节对 (ICPaLncCRPs) 开发一个管道.
探索ICPaLncCRPs作为癌症预后和ICI治疗反应的生物标志物的潜力.

主要方法:

使用免疫细胞系和免疫排斥常数 (ICR) 组数据提取与免疫相关的ICPs和lncRNAs.
构建ICPaLncCRP网络以确定监管模式.
使用批量和单细胞RNA测序数据对免疫细胞透的相关性分析.
验证ICPaLncCRPs用于预测独立数据集中的预后和ICI反应.

主要成果:

识别常见和特定的枢纽ICPaLncs (例如,MIR155HG,TRG-AS1,PCED1B-AS1) 可能对预后和循环生物标志物至关重要.
枢纽ICPaLncs与免疫细胞透的显著相关性.
证明特定的ICPaLncCRPs (例如,IDO1-MIR155HG) 可以预测黑色素瘤的预后.
验证ICPaLncCRPs作为六个独立数据集中的ICI响应的有效预测器.

结论:

这项研究增强了对瘤免疫中的lncRNA功能的理解.
已识别的ICPaLncCRPs作为预测癌症预后和对ICI治疗的反应的有希望的生物标志物.
加快了基于 lncRNA 的生物标志物的发现,以优化 ICI 治疗策略.

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