氧化治疗对胸腔体积和胸腔血管度指数的影响
Nasiq Hasan1, Matthew Driban2, Abdul Rasheed Mohammed3
1Dr. Agarwal's Eye Hospital, Tirunelveli, Tamil Nadu, India.
Eye (London, England)
|September 28, 2023
概括
基氨酸 (HCQ) 治疗与胆管体积和血管性指数的减少有关,特别是在较高的累积剂量时. 这些生物标志物可能有助于预测HCQ视网膜病变,并指导风湿病患者的治疗决策.
科学领域:
- 眼科医生 眼科 眼科
- 类风湿病学 类风湿病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 氧化 (HCQ) 广泛用于类风湿病.
- 由于潜在的眼部毒性,监测HCQ视网膜病变至关重要.
- 冠状腺变化可能是毒性的早期指标.
研究的目的:
- 在接受HCQ治疗的患者中,研究胸腔体积 (CV) 和胸腔血管度指数 (CVI) 的变化.
- 确定潜在的生物标志物,以便早期检测HCQ诱导的眼睛变化.
主要方法:
- 对137名接受HCQ治疗的成年患者的回顾性分析.
- 使用光谱域光学连贯性断层扫描进行CV和CVI的评估.
- 与年龄匹配的对照和回归分析进行HCQ剂量关联的比较.
主要成果:
- 与对照组相比,接受HCQ治疗的患者的CV和CVI显著降低.
- 增加的累积HCQ剂量与心血管衰退相关 (p=0.006).
- 在HCQ组中,光线面积也显著减少.
结论:
- 在接受HCQ治疗的患者中,胆管体积和血管度指数显著降低.
- 这些发现表明CV和CVI可以作为HCQ视网膜病变的早期生物标志物.
- 这项分析提供了新的见解,以指导HCQ治疗中的临床决策.
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