糖尿病视网膜病变对AMD相关的1型黄斑新血管化的纵向形态变化的影响
Pasquale Viggiano1, Luca Landini2, Maria Oliva Grassi2
1Department of Translational Biomedicine Neuroscience, University of Bari "Aldo Moro", Piazza Giulio Cesare, 11, Bari, Italy. pasquale.viggiano90@gmail.com.
Scientific reports
|September 28, 2023
概括
糖尿病视网膜病变 (DR) 可能会降低抗VEGF疗法的有效性,以治疗与年龄相关的湿斑变性 (AMD). 患有DR的眼睛在治疗后的新血管化区域的减少较小.
科学领域:
- 眼科医生 眼科 眼科
- 医疗成像医学成像
- 视网膜疾病 视网膜疾病
背景情况:
- 糖尿病视网膜病变 (DR) 是糖尿病的一个常见并发症.
- 1型黄斑新血管化 (MNV) 是排泄性与年龄相关的黄斑退化 (AMD) 的一个关键特征.
- 对于DR对AMD相关的MNV治疗的影响尚未完全理解.
研究的目的:
- 研究DR对AMD相关的1型MNV纵向形态变化的影响.
- 为了比较DR患者和无DR患者的治疗反应.
主要方法:
- 纳入了50个以前没有接受过治疗的眼睛,这些眼睛患有排泄性AMD和1型MNV.
- 二十个眼睛有轻度的DRD.
- 光学连贯断层扫描血管造影 (OCTA) 用于评估MNV病变区域,流量区域,中央黄斑厚度 (CMT) 和最佳校正的视力敏度 (BCVA) 在静脉内膜阿弗利塞普特注射的加载阶段之前和之后.
主要成果:
- 在两组治疗后,所有测量参数都发生了显著的变化.
- 与DR眼相比,没有DR的眼睛显示MNV区域的显著减少 (P=0.023).
- 在其他参数方面,两组之间没有发现显著差异.
结论:
- 糖尿病视网膜病变可能导致抗VEGF治疗后MNV区域减少的反应减少.
- 需要进一步的研究来了解DR对AMD治疗结果的影响.
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