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可以抑制腹膜化,这是封装腹膜硬化症的晚期特征
Seishi Aihara1, Shunsuke Yamada1, Shumei Matsueda1
1Department of Medicine and Clinical Science, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 8128582, Japan.
Scientific reports
|September 28, 2023
概括
补充可以防止腹结石和纤维化,在患有封装腹硬化症 (EPS) 且接受长期腹透析 (PD) 的患者. 这项研究表明,可以减轻动物模型和细胞培养中的关键病理变化.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學.
- 病理学 病理学 病理学
- 生物化学 生物化学
背景情况:
- 腹膜化是长期腹膜透析 (PD) 患者的重要并发症,特别是那些患有囊括性腹膜硬化症 (EPS) 患者.
- 腹膜化的潜在机制和有效的预防策略尚不清楚.
研究的目的:
- 在EPS中调查腹结石的病原性.
- 评估补充剂作为预防腹膜化和纤维化预防策略的潜力.
主要方法:
- 来自EPS患者的腹膜样本的组织学检查.
- 在小鼠中诱导腹腔化,使用腺素,脂多糖和高/溶液.
- 在化介质中培养小鼠腹膜,人类中皮细胞 (MeT5A) 和小鼠胚胎纤维细胞 (MEFs).
- 评估骨质细胞分化标志物,细胞外矩阵化和亡.
- 在体内和体外对对这些参数的影响的评估.
主要成果:
- 在EPS患者的内脏腹膜中观察到骨质细胞分化标志物.
- 在小鼠中,腹膜内的使用抑制了腹膜纤维化和化.
- 可以防止细胞外矩阵化,骨质细胞转分化和亡在暴露于化条件下的培养细胞中.
结论:
- 酸盐负载通过腹膜化和纤维化促进EPS的进展.
- 在实验模型中,补充显示有保护作用,减轻腹结石和纤维化.
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