与疫苗反应的地理差异相关的免疫学因素
Marloes M A R van Dorst1, Jeremia J Pyuza1,2, Gyaviira Nkurunungi3,4
1Department of Parasitology, Leiden University Center for Infectious Diseases, Leiden University Medical Center, Leiden, Netherlands.
Nature reviews. Immunology
|September 28, 2023
概括
疫苗的有效性因地区而异,在低收入地区观察到的保护程度较低. 了解潜在的免疫学因素对于改善全球疫苗反应至关重要.
科学领域:
- 免疫学 免疫学 免疫学
- 疫苗学 疫苗学 疫苗学
- 全球健康 全球健康
背景情况:
- 疫苗的有效性显示出显著的地理差异,影响公共卫生结果.
- 例如疟疾,菌卡尔梅特 - 盖林 (BCG),轮状病毒和黄热病疫苗.
- 环境因素,如病原体暴露,微生物群和饮食影响疫苗反应.
研究的目的:
- 审查导致疫苗反应地理差异的免疫学因素.
- 确定因果关系途径,将环境因素与疫苗反应性联系起来.
- 在表现不佳的地区,为提高疫苗疗效的策略的制定提供信息.
主要方法:
- 对影响疫苗反应的免疫学因素的文献综述.
- 对疫苗免疫性和疗效环境影响的分析.
- 下游免疫机制的探索.
主要成果:
- 疫苗疗效的地理差异是一个重大的全球卫生挑战.
- 环境因素与宿主免疫相互作用,调节疫苗的有效性.
- 目前针对个别因素的干预措施表现出有限的成功.
结论:
- 需要更深入地了解免疫机制,以解决疫苗疗效的地理差异.
- 确定因果途径可以导致调节疫苗反应的新策略.
- 开发补充性化合物可以在资源有限的环境中改善疫苗结果.
相关概念视频
Vaccinations
44.6K
Overview
44.6K
Immunological Memory
652
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
652
Cross-reactivity
31.2K
Overview
31.2K
Factors Affecting the Risk of Infection
11.9K
The hosts' susceptibility to infection depends on several factors. The integrity of the skin and mucous membranes helps protect the body against microbial attacks. When the skin is altered, the chance of infection, limb loss, and even death increases.
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
11.9K
Autoimmune Disorders
481
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
Concept and Mechanism of Autoimmune Diseases
The immune...
481
Development of Immunocompetence
339
The initiation of cell-mediated immunity can be observed as early as the third month of fetal growth, with active antibody-mediated immunity following approximately one month later.
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
The initial cells that migrate from the fetal thymus settle within the skin and epithelial tissues lining the mouth, digestive tract, and in females, the uterus and vagina. These cells, including skin-based dendritic cells, serve as antigen-presenting cells, playing a key role in T cell activation.
Subsequent T...
339


