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部推进治疗对阻塞性睡眠呼吸暂停中心脏自主功能的影响

Seren Ucak¹, Hasthi U Dissanayake^2,3, Kate Sutherland^2,3

¹Charles Perkins Centre and Northern Clinical School, Faculty of Medicine and Health, University of Sydney, Sydney, Australia. seren.ucak@sydney.edu.au.

Sleep & breathing = Schlaf & Atmung

|September 28, 2023

概括

对阻塞性睡眠呼吸暂停 (OSA) 进行的下前进 splint (MAS) 治疗改善了心脏自主功能,由延长的 NN 间隔表明. 这表明在成功治疗睡眠呼吸暂停后,自主适应能力更好.

科学领域:

心脏病学心脏病学
睡眠医学睡眠医学
自主神经科学自主神经科学

背景情况:

阻塞性睡眠呼吸暂停 (OSA) 与由于自主功能障碍引起的心血管并发症有关.
心率变化 (HRV) 分析是评估心脏自主功能的一个有价值的工具.
部推进 (MAS) 治疗是OSA的常见治疗方法,但它对心脏自主功能的影响需要进一步阐明.

研究的目的:

研究MAS治疗对OSA患者心脏自主功能的影响.
在OSA患者的MAS治疗前后分析HRV参数的变化.
为了将HRV的变化与通过呼吸暂停-呼吸暂停指数 (AHI) 测量的OSA严重程度相关联.

主要方法:

在三个前性研究中利用了101名OSA患者的多睡眠图 (PSG) 的心电图数据.
分析了N2睡眠期间的HRV参数,使用2分钟的时段与30秒的转换.
雇员配对t测试用于治疗前后的比较和回归分析,以将HRV变化与AHI变化联系起来.

主要成果:

MAS治疗显著降低了OSA的严重程度 (AHI减少了18次/小时,p<0.001).
观察到的趋势是增加LF:HF比率,LF功率和降低HF功率 (p <0.05对所有).
在NN间隔的变化和AHI的变化之间发现了显著的相关性 (p = 0.005).

结论:

成功治疗OSA的MAS与HRV的有利变化有关.
延长NN间隔,一个关键的HRV标志物,表明MAS治疗后心脏自主适应能力得到改善.
虽然时间域HRV标志物没有显著变化,但频域标志物和NN间隔表明对自主功能的积极影响.

关键词:

自主功能自主功能心血管疾病是什么心血管疾病心率变化心率的变化.部提升 splint 部提升 splint 部提升 splint 部提升 splint 部提升 splint 阻塞性睡眠呼吸暂停阻塞性睡眠暂停

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