带疹与人类免疫缺陷病毒感染者的中风发病率相关:一项嵌套病例对照研究
Han-Chang Ku1, Yi-Lin Wu2, Hei-Tung Yip3
1Department of Nursing, Chang Gung University of Science and Technology, Chiayi Branch, Chiayi, Taiwan.
BMC infectious diseases
|September 28, 2023
概括
疹疹 (HZ) 感染可能会增加患有人类免疫缺陷病毒 (HIV) 的人的中风风险. 早期的HZ预防策略对这一群体至关重要.
科学领域:
- 传染性疾病 传染性疾病
- 神经学 神经学
- 公共卫生 公共卫生
背景情况:
- 患有人类免疫缺陷病毒 (HIV) 的年轻人中中风发生率正在上升.
- 疹 (HZ) 感染与一般人群中较高的中风风险有关.
- 艾滋病毒患者中HZ和中风之间的特定关联仍然不清楚.
研究的目的:
- 研究人类免疫缺陷病毒 (HIV) 患者中疹 (HZ) 感染和中风发病率之间的关联.
- 为了确定艾滋病毒感染个体中中风风险因素.
主要方法:
- 一项嵌套病例控制研究利用了台湾国家健康保险研究数据库 (2000-2017年).
- 509例中风病例与5090例基于年龄,性别和诊断日期的非中风对照进行了匹配.
- 使用后勤回归模型计算中风发生率的几率比率 (OR) 和95%置信区间 (CI).
主要成果:
- 患有HZ的HIV感染患者的中风几率比率显著更高 (AOR: 1.85,95%CI: 1.42-2.41).
- 高血压 (AOR:3.53),心脏病 (AOR:2.32) 和慢性病 (AOR:1.82) 与中风风险增加有显著联系.
- 型肝炎病毒感染 (AOR: 1.49),高脂血症 (OR: 1.41) 和蛋白酶抑制剂使用 (AOR: 1.33) 也增加了中风风险.
结论:
- 与艾滋病病毒并发的疹 (HZ) 感染可能会增加中风风险.
- 这一群人中风发病率独立于常见的风险因素,突出显示HZ是关键问题.
- 建议艾滋病毒感染者采取HZ感染的早期预防策略.
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