与质子抑制剂相关的功能下降:ELSA-巴西队列研究的结果
Andrêza Soares Dos Santos1, Sara Teles de Menezes2, Isabella Ribeiro Silva1
1Postgraduate Program in Health Sciences, Universidade Federal de São João del-Rei, Sebastião Gonçalves Coelho Street, 400 - Chanadour, Divinópolis, 35501-296, MG, Brazil.
BMC nephrology
|September 28, 2023
概括
质子抑制剂 (PPI) 的使用,特别是超过六个月,与慢性病 (CKD) 的更高风险和随着时间的推移,功能下降的速度更快有关.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 药理学 药理学是指药理学的学科.
- 流行病学 流行病学
背景情况:
- 质子抑制剂 (PPI) 是广泛使用的药物.
- 个人消毒剂对脏健康的长期影响尚未完全理解.
- 调查PPI使用与慢性病 (CKD) 之间的关联至关重要.
研究的目的:
- 检查使用质子抑制剂 (PPI) 与慢性病 (CKD) 发生率之间的纵向关联.
- 评估PPI使用时间和随时间变化的功能之间的关系.
- 评估PPI对大队伍功能的影响.
主要方法:
- 一项前性研究,涉及来自ELSA-巴西队列的13,909名参与者.
- 从基线 (2008-2010) 和第二波 (2012-2014) 收集的数据,平均间隔为3.9年.
- 使用估计的淋巴细胞过率 (eGFR) 评估功能;发生的CKD定义为EGFR<60mL/min/1.73m2在第2波.
主要成果:
- 与非使用者相比,使用质子抑制剂 (PPI) 超过六个月的患者患慢性病 (CKD) 的风险增加.
- 短期 (长达六个月) 和长期 (超过六个月) 的PPI使用都与功能更大的下降有关.
- 经过调整后的分析证实了这些关联,突出了剂量依赖或持续时间依赖的影响.
结论:
- 质子抑制剂 (PPI) 的使用,特别是其持续时间,在纵向上与功能变化有关.
- 这项研究表明,PPI对成人和老年人的脏健康存在潜在风险.
- 需要进一步的研究来阐明这种关联和临床影响背后的机制.
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