评估精液DNA完整性和相关参数与COVID-19感染:一个前性队列研究
Shuibo Shi1, Hongji Hu1, Jiayao Wang1
1Department of Assisted Reproduction, the First Affiliated Hospital of Nanchang University, Yongwai Street 17, Nanchang City, Jiangxi Province, China.
Virology journal
|September 28, 2023
概括
COVID-19感染显著影响男性生殖健康,降低精子质量并增加DNA碎片化. 这一发现凸显了该病毒对男性生育能力的不利影响.
科学领域:
- 生殖医学 生殖医学
- 病毒学 病毒学
- 遗传学 是一个遗传学.
背景情况:
- 随着COVID-19的流行,人们对其对男性生殖功能的潜在影响感到担忧.
- 了解这些影响对于公共卫生和临床管理至关重要.
研究的目的:
- 调查COVID-19感染对精液质量和精子DNA完整性的影响.
- 评估COVID-19和男性生育能力参数之间的关系.
主要方法:
- 进行了一项前性队列研究,涉及132名参与者 (78名COVID-19阳性,54名阴性).
- 用WHO标准,CASA和SCSA来评估DNA损伤 (DFI) 的精液质量进行了评估.
主要成果:
- 与阴性个体相比,COVID-19阳性个体的精子度,渐进性运动能力和运动能力显著降低.
- 在COVID-19阳性组中观察到显著更高的精子DNA碎片化指数 (DFI).
结论:
- COVID-19感染对男性生育能力产生不利影响,特别是通过增加精子DNA碎片化.
- 这些发现为在COVID-19后管理男性生殖健康的临床医生提供了重要的咨询指导.
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