在COVID-19中血清神经丝光链和功能影响的功能
Peter Körtvelyessy1,2, Elena Diekämper3, Klemens Ruprecht4
1Department of Neurology, Charité - Universitätsmedizin Berlin, Freie Universität Berlin and Humboldt-Universität zu Berlin, Hindenburgdamm 30, 12200, Berlin, Germany. peter.koertvelyessy@charite.de.
European journal of medical research
|September 28, 2023
概括
在COVID-19患者中血清神经丝光链 (sNfL) 的升高与不良结果有关. 然而,功能障碍也会增加sNfL,这表明在评估神经轴损伤时,它可能会混结果.
科学领域:
- 神经学 神经学
- 生物标志物 生物标志物
- 传染性疾病 传染性疾病
背景情况:
- COVID-19 呈现出各种神经系统症状.
- 血清神经丝光链 (sNfL) 是神经轴损伤的标志物.
- 升高的sNfL已与COVID-19的不良结果有关,但认可了功能障碍和缺氧等混因素.
研究的目的:
- 调查sNfL水平与COVID-19患者的临床结果之间的关系.
- 评估氧气治疗和功能对sNfL水平的影响.
- 澄清sNfL在COVID-19中升高的机制和意义.
主要方法:
- 在48名COVID-19患者中评估了sNfL水平.
- 与临床结果相关的sNfL水平,氧气治疗类型 (鼻腔管,高流量,机械通风) 和血清肌.
- 进行年龄调整并将sNfL水平与正常值和z-score进行比较.
主要成果:
- 在接受鼻管和高流氧的患者中,sNfL水平正常.
- 在机械通风ICU患者中观察到明显更高的sNfL水平 (p < 0.01).
- sNfL升高与不良结果有很强的相关性 (p < 0.01),血清肌素水平 (p < 0.01).
- 多变量分析表明,sNfL和血清肌素都与临床结果相关.
结论:
- 功能障碍是COVID-19中sNfL升高的重要混因素.
- 在使用sNfL作为COVID-19生物标志物的研究中,必须考虑血清肌和功能.
- 在COVID-19中解释sNfL升高需要仔细考虑潜在的混杂因素,特别是功能障碍.
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