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女性生育能力和性发育对表观遗传钟的影响:孟德尔随机化研究

Boxin Zhang^1,2,3, Qizhi Yuan^1,2,3, Yining Luan^1,2,3

¹Department of Neurology, Xiangya Hospital, Central South University, 87 Xiangya Road of Kaifu District, Changsha, 410008, China.

Clinical epigenetics

|September 28, 2023

概括

这项研究发现,早期的第一次性交年龄 (AFS) 和第一次出生年龄 (AFB) 与加速表观遗传衰老有关. 这些发现强调了生殖时间和女性生物衰老之间的联系.

科学领域:

遗传学和表观遗传学
生殖健康生殖健康
衰老研究研究衰老研究

背景情况:

观察性研究表明,女性的生育能力和性发育特征可能会影响DNA甲基化模式.
与怀孕相关的因素也会影响母亲的DNA甲基化.
了解这些联系对于生殖健康和衰老至关重要.

研究的目的:

调查女性生育/性发展特征与表观遗传钟之间的潜在因果关系.
使用孟德尔随机化 (MR) 识别这些关系中的可能调解者.
探索BMI,第一次性交年龄 (AFS) 和第一次分娩年龄 (AFB) 作为调解者的作用.

主要方法:

利用两个样本的门德尔随机化 (MR) 分析与来自欧洲祖先个体的全基因组关联研究数据.
评估了生育/性特征与四个表观遗传时钟 (HannumAge,PhenoAge,GrimAge) 之间的关系,使用逆方差加权和其他方法.
采用多变量MR (MVMR) 和两步MR来调整混因子并探索调解效应.

主要成果:

较早的第一个出生年龄 (AFB) 与加速的HannumAge,PhenoAge和GrimAge显著相关.
初次性交的早期年龄 (AFS) 与加速的HannumAge和GrimAge显著相关.
BMI,AFB和AFS被确定为生育能力/性特征与表观遗传衰老之间的关系的调解者.

结论:

第一次性交 (AFS) 和第一次出生 (AFB) 的年龄与表观遗传衰老有关.
这些发现可以为表观遗传衰老相关疾病的预防策略提供信息.
强调在妇女健康和老龄化方面考虑生殖经验的重要性.

关键词:

AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM BAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM AAM 美国空军基地 (AFB)在 AFS AFS AFS 中.一个国家,一个国家.基因表观时钟是什么?门德尔的随机化可能存在潜在的因果关系.

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