在COVID-19感染和接种疫苗后的硬质皮质
Henry Zou1, Akash Rau2, Steven Daveluy3
1The Michigan State University College of Human Medicine, Michigan St NE, Grand Rapids, MI; zouhenry@msu.edu.
Skinmed
|September 29, 2023
概括
硬化肌,一种罕见的自身免疫性疾病,很少与COVID-19感染和接种疫苗有关. 这次审查审查了13项研究,发现了很少的病例,但强调了潜在的分子模仿和细胞因子激活是原因.
科学领域:
- 免疫学 免疫学 免疫学
- 皮肤病学 皮肤病学
- 类风湿病学 类风湿病学
背景情况:
- 硬化症是一种罕见的自身免疫结合组织疾病,导致皮肤硬化.
- 虽然已知药物诱导和副瘤病例,但与COVID-19相关的硬质皮质症很少被讨论.
- 本综述侧重于COVID-19感染和接种疫苗后的硬质皮肤病例.
研究的目的:
- 审查和综合现有的关于与COVID-19感染和疫苗接种相关的硬皮病例的文献.
- 为了确定潜在的致病机制,将COVID-19和硬质皮症联系起来.
- 为了告知临床医生关于这种罕见的潜在并发症.
主要方法:
- 从2019年到2023年1月,在MEDLINE (PubMed),Embase,Scopus和Google Scholar上进行了全面的文献搜索.
- 根据受试者的相关性和参考查,选择了13项相关研究.
- 提取了患者人口统计数据,COVID-19暴露 (感染或接种疫苗) 和硬质皮肤病特征.
主要成果:
- 在COVID-19感染后发现了四例硬质皮质炎病例 (平均年龄为54.5岁).
- 在接种COVID-19疫苗 (平均年龄为62.8岁) 后,发现了10例硬质皮质炎病例,其中包括瑞-生物科技,现代和牛津-阿斯特拉-泽内卡疫苗.
- 建议的致病机制包括分子模仿,细胞因子激活和内皮损伤.
结论:
- 硬质皮质是一个罕见的,但在COVID-19感染和接种疫苗后可能出现的并发症.
- 虽然COVID-19疫苗提供了显著的好处,但临床医生应该对这种罕见的不良事件保持警.
- 需要进一步的研究,才能充分了解COVID-19后硬质皮质炎的发病和发病率.
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