缺血性中风患者白细胞数量升高与死亡率增加和新的血管事件有关
Thao Phuong Vo1, Marie Hvelplund Kristiansen1, Hans Carl Hasselbalch2
1Neurology Department, Zealand University Hospital, University of Copenhagen, Roskilde, Denmark.
Frontiers in neurology
|September 29, 2023
概括
缺血性中风患者白细胞 (WBC) 数量升高预测了长期出现复发性血管事件和死亡率的风险较高. 这些发现强调了需要对这些患者进行仔细监测和调查潜在原因的必要性.
科学领域:
- 神经学 神经学
- 心血管医学 心血管医学
- 血液学 血液学 血液学
背景情况:
- 在短期研究中,高白细胞 (WBC) 计数与缺血性中风后增加的血管事件风险和死亡率有关.
- 缺血性中风后白细胞水平升高的长期预后影响在很大程度上是未知的.
研究的目的:
- 在缺血性中风患者的10年随访期间,研究高血小细胞水平与新血管事件的风险和全因死亡率之间的关联.
主要方法:
- 分析了在2011-2012年期间住院的395名缺血性中风患者的队列.
- 患者根据中风发作后48小时内白血球计数 (正常与升高) 进行分类.
- 考克斯比例危险模型和卡普兰-梅尔分析被用来评估长期风险.
主要成果:
- 38.5%的患者在入院时白细胞计数升高.
- 在10年内,高WBC水平独立地与新的血管事件 (HR: 1.61) 和全因死亡率 (HR: 1.55) 的显著增加风险相关.
- 与正常计数的患者相比,WBC计数升高的患者患血管事件和死亡的发病率更高.
结论:
- 在缺血性中风患者中,高WBC水平,即使没有临床感染,也是长期血管事件风险和死亡率的重要预测指标.
- 这些患者需要密切监测和调查潜在疾病,以改善结果.
- 进一步的研究应该考虑根据中风的严重程度和治疗进行调整,以完善这些发现.
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