妇女非酒精性脂肪性肝病 - - 当前知识和新兴概念
Pei Chia Eng1,2, Roberta Forlano1,3, Tricia Tan1,2
1Department of Metabolism, Digestion and Reproduction, Imperial College London, UK.
JHEP reports : innovation in hepatology
|September 29, 2023
概括
非酒精性脂肪性肝病 (NAFLD) 影响全球许多成年人. 本综述探讨了导致妇女患NAFLD/NASH的激素和非激素因素,旨在改善临床实践和研究,以获得更好的结果.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 内分泌学 在内分泌学.
- 妇女健康 妇女健康
背景情况:
- 非酒精性脂肪性肝病 (NAFLD) 是一种普遍存在的全球性肝病.
- 进展为非酒精性脂肪肝炎 (NASH) 会增加肝硬化,癌症和心血管事件的风险.
- 生殖激素的改变与女性的NAFLD/NASH发展和进展有关.
研究的目的:
- 审查影响女性NAFLD发展和进展的荷尔蒙和非荷尔蒙因素.
- 确定临床实践和未来研究女性NAFLD的关键领域.
- 提高对女性NAFLD/NASH的了解,解决较高的死亡率和移植率.
主要方法:
- 在NAFLD/NASH中对荷尔蒙和非荷尔蒙因素的文献综述.
- 分析女性特有的风险因素,包括PCOS和雌激素缺乏症.
- 在女性生理学背景下对NAFLD/NASH当前知识的综合.
主要成果:
- 患有PCOS和雌激素缺乏症的女性表现出NAFLD/NASH风险增加.
- 与同龄男性相比,患有NAFLD/NASH的老年女性的死亡率更高.
- 在没有肝细胞癌的妇女中,NAFLD/NASH是肝移植的主要适应症.
结论:
- 了解女性的NAFLD需要关注荷尔蒙的影响.
- 临床实践和研究应在NAFLD/NASH管理中优先考虑女性特异性因素.
- 更好的理解对于改善NAFLD/NASH的女性的治疗结果和降低死亡率至关重要.
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