分析一种β-乳酸过敏评估协议,挑战各种已报告的过敏,由抗菌药物管理计划管理
Max W Jacobs1, Derek N Bremmer2, Nathan R Shively3
1Medicine Institute, Allegheny Health Network, Pittsburgh, PA, USA.
Antimicrobial stewardship & healthcare epidemiology : ASHE
|September 29, 2023
概括
一个抗菌药物管理计划 (ASP) 团队开发了一种安全有效的β-乳酸过敏评估协议. 超过90%的患者耐受了挑战,使得必要的β-乳糖抗生素治疗成为可能.
科学领域:
- 传染性疾病 传染性疾病
- 临床药房 临床药房
- 过敏和免疫学 过敏和免疫学
背景情况:
- 贝塔乳酸抗生素至关重要,但由于报告过敏,经常避免服用.
- 准确的过敏评估对于优化抗生素使用和预防耐药性至关重要.
- 抗菌药物管理计划 (ASP) 可以在过敏管理中发挥关键作用.
研究的目的:
- 评估一种新的β-乳酸过敏评估算法的安全性和有效性.
- 为了确定ASP管理的过敏评估协议的有效性.
- 评估该算法的对β-乳糖抗生素利用的影响.
主要方法:
- 对接受beta-lactam挑战的患者的回顾性分析.
- 由ASP团队实施风险分层过敏评估协议.
- 收集有关患者结局,不良反应和随后抗生素使用的数据.
主要成果:
- 包括119名患有青素或胞素过敏的患者.
- 89.1%的患者可以耐受β-乳酸的挑战剂量.
- 10.6%的低风险患者出现了不良反应,高风险患者为7.1%.
结论:
- 由ASP管理的β-乳酸过敏评估协议是安全有效的.
- 该方案在大多数患者中促进了适当的β-lactam抗生素治疗.
- 该模型可以被其他ASP采用,以简化过敏评估.
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