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三维纳米纤维海绵与对齐的架构和控制的层次结构调节神经干细胞命运的脊髓再生

Zhiwei Li¹, Ye Qi², Lei Sun³

¹Department of Neurosurgery, Qilu Hospital of Shandong University and Institute of Brain and Brain-Inspired Science, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250012, China.

|September 29, 2023

概括

这项研究开发了先进的3D纳米纤维海绵,当与神经干细胞 (NSC) 结合时,可促进神经再生和脊髓损伤 (SCI) 后的功能恢复. 这些支架为治疗SCI提供了一个有希望的解决方案.

科学领域:

生物材料科学生物材料科学
神经科学是一个神经科学.
再生医学是一种再生医学.

背景情况:

脊髓损伤 (SCI) 导致神经元死亡和神经纤维损伤,导致.
目前对SCI的治疗方法有限,这凸显了对创新的治疗策略的需求.
将仿生支架与神经干细胞 (NSC) 移植相结合,显示出SCI修复的潜力.

研究的目的:

设计和开发用于脊髓修复的新型三维 (3D) 纳米纤维海绵 (NS).
研究这些3DNS对神经干细胞行为和脊髓再生的体外和体外影响.
在SCI的老鼠模型中评估NSC种植的3DNS的治疗潜力.

主要方法:

使用定向电和气泡制造3D纳米纤维海绵的制造.
在体外评估细胞透,分化和成熟的支架.
在老鼠SCI模型中的体内评估使用免疫光学,MRI,电生理学和行为测试.

主要成果:

3DNS具有对齐的纳米架构,高孔隙性,水友性和合适的机械性能.
支架促进了NSC透,对齐,神经元分化和成熟.
在体内,NSC种植的3DNS促进了SCI大鼠的轴突再内核化,复髓化和显著的功能恢复,恢复了运动分数和电生理信号.

结论:

制造的3DNS有效调节神经干细胞的命运.
这种先进的3DNS设计和NSC移植的组合是SCI修复的理想组织工程支架.
开发的支架显示出在脊髓损伤后促进神经再生和功能恢复的巨大潜力.

关键词:

电子旋转是一种电子旋转.纳米纤维海绵是一种海绵.神经干细胞的神经干细胞神经组织工程. 神经组织工程.脊髓损伤导致的脊髓损伤

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