补充了微质部分救助精神分裂症相关的应激反应
Ling Yan1, Fang-Ling Xuan1, Song Chen2
1Institute of Biomedicine and Translational Medicine, Faculty of Medicine, University of Tartu, Tartu, Estonia.
微质的补充通过改善压力诱导的行为缺陷和大脑变化,显示出治疗精神分裂症的前景. 这种疗法可能有助于在精神疾病中恢复大脑平衡.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 免疫学 免疫学 免疫学
背景情况:
- 微质对大脑和行为稳定至关重要.
- 微质的补充已经在神经疾病中显示出好处.
- 它在精神疾病,如精神分裂症,特别是与压力相关的形式的疗效尚不清楚.
研究的目的:
- 研究微质补充在与压力相关的精神分裂症的治疗潜力.
- 了解慢性压力背景下微质补充的基础机制.
主要方法:
- 利用CSF1R介导的药理方法,在患有慢性不可预测压力 (CUS) 的小鼠中进行微质补充.
- 检查了第一发精神分裂症 (FES) 患者和健康对照组 (HCs) 的队列,评估感知压力得分 (PSS) 和海马片膜大小.
- 分析了前额皮质和血液中的差异表达基因 (DEG),以及微质形态.
主要成果:
- 在小鼠中,微质补充 (repMg) 缓解了CUS诱导的学习绝望和社会退缩,但没有缓解焦虑.
- CUS和repMg改变了前额叶皮层中与神经系统发育和轴突引导相关的基因表达.
- CUS诱导了微质高分支和突触组件的增加吞,这些被repMg扭转了.
- FES患者表现出较小的海马膜,与PSS负相关.
- 参与免疫系统发育的血液DEG与FES患者的PSS和fimbria大小有关.
结论:
- 微质补充可能为精神疾病如精神分裂症提供潜在的治疗策略.
- 这些发现表明,微质功能和免疫系统途径在与压力相关的精神分裂症的病理生理学中起着作用.
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