单独或与吸烟和饮酒相结合的MTHFR多态性对癌症易感性的影响
Yonghui Huang1, Qiurui Hu1, Zhenxia Wei2
1Department of Prosthodontics, The Affiliated Stomatology Hospital of Guangxi Medical University, Nanning 530021, P. R. China.
Open life sciences
|September 29, 2023
概括
MTHFR C677T多态性增加了吸烟的癌症风险,特别是肝癌. 与饮酒者不同的是,MTHFR C677T变异的非饮酒者也面临更高的癌症风险.
科学领域:
- 遗传学和瘤学 在
- 分子流行病学分子流行病学
- 环境健康 环境健康
背景情况:
- 通过调节叶酸代谢,5,10-甲基基叶酸减少酶 (MTHFR) 突变与癌症的发展有关.
- 关于MTHFR基因变异,吸烟和饮酒与癌症风险之间的相互作用的先前研究产生了不一致的结果.
- 了解这些基因与环境的相互作用对于癌症风险评估和预防策略至关重要.
研究的目的:
- 量化评估MTHFR基因多态化 (C677T和A1298C) 与吸烟和饮酒对癌症发展的综合影响.
- 通过全面的元分析,评估各种癌症类型中基因吸烟和基因饮酒相互作用的程度.
主要方法:
- 在主要数据库 (PubMed, Web of Science, CNKI, Wan Fang) 进行了系统的文献搜索,截至2022年5月.
- 使用Stata v11.2进行了元分析,以计算MTHFR多态的几率比率 (OR) 和95%置信区间 (95%CI).
- 根据种族,对照来源和癌症类型的分层分析,以及敏感性和出版偏差分析 (贝格,埃格尔测试) 被使用.
主要成果:
- 当与吸烟相结合时,MTHFR C677T多态性显示出与癌症风险增加的显著关联 (OR=1.225,95% CI [1.009-1.487]).
- 这种相互作用显著增加了肝癌风险 (OR=1.564,95% CI [1.014-2.413]),特别是在亚洲吸烟者中 (OR=1.292,95% CI [1.007-1.658]).
- A1298C多态性与混合种群的癌症风险增加有关,并且与吸烟相结合时 (OR=1.531,95% CI [1.127-2.080]).
- 在非饮酒者中,C677T多态与食道癌 (OR=1.544,95%CI [1.011-2.359]) 和结肠癌 (OR=1.877,95%CI [1.166-3.054]) 风险有关,但在饮酒者中没有发现这种联系.
结论:
- 与吸烟相结合的MTHFR C677T多态性显著增加癌症风险,特别是肝癌.
- MTHFR C677T变异与非饮酒者癌症风险增加有关,这表明饮酒可能会减轻这种遗传风险.
- 这些发现强调了基因与环境相互作用的重要性,特别是MTHFR与吸烟和酒精的多态性,在癌症病因学中.
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