相关实验视频
Updated: Jul 15, 2025
09:46
Accessing the Cytotoxicity and Cell Response to Biomaterials
Published on: July 8, 2021
3.7K
补充含有Poloxamer 407的酸水泥对细胞活动的影响
Yeeun Kim1, Kenichi Hamada1, Kazumitsu Sekine1
1Department of Biomaterials and Bioengineering, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Journal of biomedical materials research. Part B, Applied biomaterials
|September 29, 2023
概括
将poloxamer 407添加到改性β-三酸 (mβ-TCP) 水泥中可以增强骨修复特性,而不会对骨质母细胞生长产生负面影响. 这种新的组合显示出对骨再生应用的希望.
科学领域:
- 生物材料科学 生物材料科学
- 再生医学是一种再生医学.
- 整形外科手术 整形外科手术
背景情况:
- 酸水泥 (CPC) 是骨修复的一个关键材料.
- 作为表面活性剂的波洛克萨默斯在药物输送方面具有潜力,但它们对骨再生的影响尚不清楚.
- 了解波洛克萨默对骨移植材料的生物影响至关重要.
研究的目的:
- 为了研究添加波洛克萨默407对新型改性β-三酸 (mβ-TCP) 水泥细胞活动和骨再生能力的影响.
- 评估波洛克萨默对mβ-TCP水泥机械性质和骨质细胞反应的影响.
主要方法:
- 一种新的mβ-TCP粉末是使用行星球磨粉工艺合成的.
- 将Poloxamer 407添加到mβ-TCP水泥中,其度为0.05和0.1g/mL.
- 在体外研究评估了MC3T3-E1细胞活力,附着和形态在mβ-TCP水泥上的mβ-TCP水泥与没有poloxamer.
主要成果:
- mβ-TCP水泥表现出快速溶解,加快酸沉,减少定时间,增强强度.
- 添加Poloxamer 407提高了断裂性和降低了泄漏风险,而不会损害机械性能.
- 在mβ-TCP和poloxamer修饰的mβ-TCP组之间,MC3T3-E1细胞活力是可比的.
- 在所有测试样本上观察到有效的细胞附着和健康的骨质母细胞形态.
结论:
- 除了mβ-TCP水泥外,Poloxamer 407对骨质细胞的生长和功能是安全的.
- 结合mβ-TCP和poloxamer 407,为骨缺陷的修复和再生提供了一个有前途的生物材料.
- 这种新的配方为骨科应用提供了潜在的治疗优势.
相关概念视频
01:24Hydration of Cement
271
Hydration of cement is a chemical reaction between cement particles and water. This process occurs primarily through two mechanisms: through-solution and topochemical. In the through-solution process, anhydrous compounds dissolve into their constituents, hydrates form in the solution, and then precipitate from the supersaturated solution. The topochemical process involves solid-state reactions at the cement particle surface. The through-solution process dominates the topochemical process at the...
271
01:21Pozzolans
137
Pozzolans are siliceous or aluminous materials blended with Portland cement. They interact with the calcium hydroxide produced during the hydration of Portland cement and contribute to improved strength and durability of concrete. The pozzolanic activity, a measure of a pozzolan's effectiveness, is typically assessed using the strength activity index, as defined in ASTM C 618-93, which calculates the ratio of the compressive strength of cement mixtures with and without pozzolan.
Fly ash is...
Fly ash is...
137
01:31Plasticizers
86
Water-reducers, or plasticizers, are chemical admixtures used in concrete to improve strength and workability. These additives reduce the water-cement ratio without compromising workability, lower the cement content while maintaining the same workability, or increase workability to assist concrete placement in inaccessible areas.
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
Plasticizers function by using surface-active agents to create repulsive electrostatic forces between cement particles. This dispersion enhances the concrete's...
86