光学连贯性断层扫描与其他生物标志物相比:在多发性硬化症中与身体和认知障碍的关联
Nuria Cerdá-Fuertes1,2,3,4, Marc Stoessel1,2,3, Gintaras Mickeliunas5
1Department of Clinical Research, University Hospital of Basel, University of Basel, Basel, Switzerland.
概括
光学连贯断层扫描 (OCT) 测量了多发性硬化症 (MS) 中的神经轴损失. OCT是MS分层的一个有价值的工具,独立于MRI和血清标记,有助于评估残疾.
科学领域:
- 神经科学是一个神经科学.
- 眼科医生 眼科 眼科
- 放射学 放射学是一门学科.
背景情况:
- 光学连贯断层扫描 (OCT) 是检测多发性硬化症 (MS) 中神经轴损失的关键生物标志物.
- 了解海外国家和地区与其他生物标志物的作用对于MS管理至关重要.
研究的目的:
- 评估OCT与磁共振成像 (MRI) 和血清标记器在MS患者中评估残疾的比较意义.
- 确定海外国家和地区措施在预测残疾方面的独立贡献.
主要方法:
- 100名多发性硬化患者和52名对照人群接受了OCT测量周囊状视网膜神经纤维层 (pRNFL) 和状细胞内状层 (GCIPL).
- 血清神经纤维光链 (sNfL),总损伤体积 (TLV) 和大脑辅酶分数 (BPF) 进行了评估.
- 线性回归模型分析了OCT措施与残疾之间的关联,控制共变量.
主要成果:
- pRNFL与符号数字模式测试 (SDMT) 相对应.
- 在多变量分析中,pRNFL和TLV与SDMT相关,而GCIPL和sNfL与扩展残疾状况量表 (EDSS) 显示了最强的关联.
- 海外国与地区的测量表明,与认知障碍和身体障碍有关.
结论:
- 来自OCT的神经轴突损失与MS中的残疾有关,独立于MRI和血清标志物.
- 超越国土和地区作为一个有价值的工具,用于MS患者分层.
- 建议进一步进行结合多个生物标志物的纵向研究.
相关概念视频
Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests
Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
Multiple Sclerosis l: Introduction
Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...


