抑郁症症状和多发性硬化症的认知:纵向证据表明,与执行控制有特定的联系
Jordyn R Anderson1, Kathryn C Fitzgerald2, James W Murrough3
1Corinne Goldsmith Dickinson Center for Multiple Sclerosis, Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
概括
多发性硬化症 (MS) 患者抑郁症症状的变化与执行控制进行纵向跟踪,而不是认知速度或记忆. 管理情绪可能会改善MS的执行功能.
科学领域:
- 神经科学是一个神经科学.
- 精神病学是一个精神病学.
- 临床神经学 临床神经学
背景情况:
- 抑郁症症状在多发性硬化症 (MS) 中很常见,并且在横截面研究中与认知能力下降有关.
- 缺乏关于抑郁症症状变化和MS认知变化之间的关系的纵向数据.
研究的目的:
- 为了确定抑郁症症状的变化是否与MS患者随着时间的推移与认知变化相对应.
- 为了确定与MS中抑郁症症状变化相关的特定认知功能.
主要方法:
- 165名早期复发性多发性硬化症患者在基线和3年随访期间完成了抑郁症和认知评估.
- 评估的认知领域包括认知速度,执行控制和记忆.
- 单向ANOVA分析了基于抑郁症症状变化的认知变化 (恶化,稳定,改善).
主要成果:
- 在抑郁症症状的变化和执行控制的变化之间发现了显著的关系 (p = 0.001).
- 抑郁症的恶化与执行控制的下降相关,而抑郁症的改善与执行控制的改善相关,独立于认知速度.
- 在抑郁症症状变化和认知速度或记忆的变化之间没有观察到显著的关联.
结论:
- 执行控制在MS中纵向跟踪抑郁症状.
- 旨在管理情绪的干预措施可能会改善MS患者的执行控制.
- 执行控制与无情感等特定症状之间的联系表明,奖励处理缺陷是MS相关抑郁症的核心.
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