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在急性呼吸道感染中用于病原体鉴定的废纸纸巾
Annabel Rector1, Mandy Bloemen1, Marc Van Ranst1,2
1Laboratory of Clinical and Epidemiological Virology, Department of Microbiology, Immunology and Transplantation, Rega Institute, KU Leuven, Leuven, Belgium.
Journal of medical virology
|September 29, 2023
概括
使用的纸质组织 (UPT) 为诊断呼吸道感染提供了一种新的非侵入性方法. 这种方法有效地检测到个人和社区环境中的各种病毒和细菌病原体.
科学领域:
- 传染性疾病 传染性疾病
- 诊断微生物学 诊断微生物学
- 公共卫生 公共卫生
背景情况:
- 准确和可访问的诊断对于管理急性呼吸道感染至关重要.
- 传统的采样方法,如鼻子抽样,在某些人群中可能具有侵入性和挑战性.
- 对非侵入性,社区级监控工具的需求正在增加.
研究的目的:
- 评估使用纸巾 (UPT) 作为急性呼吸道感染的非侵入性诊断样品的有效性.
- 评估UPT在检测广泛的呼吸道病原体方面的实用性.
- 探索UPT在个人患者诊断和社区流行病学监测中的应用.
主要方法:
- 在2022-2023年比利时冬季/春季季节从个人那里收集过的纸巾 (UPT).
- 使用内部呼吸系统面板同时检测22种呼吸系统病毒和7种非病毒性病原体.
- 在UPT中比较病原体检测与并发的鼻和抗原检测快速诊断测试.
主要成果:
- 在鼻中发现的病原体也可以在相应的UPT样本中检测到.
- 所有积极的病毒快速诊断测试与UPT中的病原体检测相关.
- 在UPT中发现了多种呼吸道病原体,包括SARS-CoV-2,流感,RSV,肠道病毒和肺炎链球菌.
- 来自集体样本的UPT成功识别了病原体,证明了社区测试的适用性.
结论:
- 使用的纸张组织 (UPT) 是一种可行的非侵入性工具,用于诊断急性呼吸道感染.
- UPT采样对于检测广泛的常见呼吸道病原体是有效的.
- 这种方法显示出在传统采样难以实现的环境中,流行病学监测和社区查的巨大潜力.
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