阳性活检核心率对中等风险前列腺癌中低剂量率支臂治疗结果的影响
Yoshito Kusuhara1, Tomoya Fukawa2, Tomoharu Fukumori3
1Department of Urology, Tokushima University Graduate School of Biomedical Sciences, Tokushima, Japan.
Anticancer research
|September 29, 2023
概括
活检阳性核心比率预测中等风险前列腺癌 (PCa) 治疗低剂量率支臂治疗 (LDR-BT) 的复发. 格里森等级组3 (GG3) PCa的患者尤其如此,这表明它对预测结果的重要性.
科学领域:
- 在瘤学瘤学.
- 辐射瘤学 辐射瘤学
- 泌尿器科 泌尿器科 泌尿器科 泌尿器科
背景情况:
- 中等风险前列腺癌 (PCa) 是异质的.
- 低剂量率支臂治疗 (LDR-BT) 是中等风险PCa的标准治疗方法.
- 关于ISUP等级组 (GG) 2和GG3中等风险PCa患者接受LDR-BT治疗的结果差异的数据有限.
研究的目的:
- 调查日本中等风险PCa患者之间的结果差异,特别是比较用LDR-BT治疗的GG2和GG3组.
- 确定这些患者群体中复发的预测因素.
主要方法:
- 一个单一中心的回顾性研究,对342名连续的中期风险PCa患者 (232名GG2,110名GG3) 进行了单一中心的回顾性研究.
- 所有患者在2004年7月至2019年12月期间接受了LDR-BT.
- 分析的结果包括无生物化学进展生存率和癌症特异性生存率.
主要成果:
- 在GG2和GG3组之间没有观察到5年无生物化学进展生存或癌症特异性生存的显著差异.
- 多变量分析确定了辐射剂量达到前列腺体积的90% (D90) 和阳性活检核的百分比作为所有中等风险PCa患者的复发预测指标.
- D90预测了GG2患者的复发,而高比例的阳性核预测了GG3患者的复发.
结论:
- 前列腺活检上的正核比率与LDR-BT后的更高复发率相关.
- 阳性核的比例是预测复发风险的关键因素,特别是在GG3中等风险PCa患者中.
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