阴道内皮质新生病的结肠镜图案和组织学等级之间的相关性:一个回顾性队列研究
Ermelinda Monti1, Cristina Maria Michela Matozzo2, Giulia Emily Cetera1
1Gynecology Unit, Fondazione Istituto di Ricovero e Cura a Carattere Scientifico Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Anticancer research
|September 29, 2023
概括
在诊断阴道内皮质瘤 (VaIN) 时,镜精度有限,整体诊断精度为59.7%. 虽然主要的结肠镜异常与高度VaIN相关,但I级发现并不排除高度病变.
科学领域:
- 妇科 妇科 妇科 妇科
- 在瘤学瘤学.
- 病理学 病理学 病理学
背景情况:
- 阴道内皮质瘤 (VaIN) 是一种罕见的先发性疾病,与人类乳头瘤病毒 (HPV) 有关.
- 诊断依赖于下生殖道疾病专家的镜导向活检.
研究的目的:
- 为了评估所有级别的VaIN.的结肠镜的诊断准确性.
- 评估结肠镜检测结果与VaIN组织学等级之间的相关性.
主要方法:
- 在2010-2022年间诊断出VaIN1,VaIN2或VaIN3的149名妇女的回顾性分析.
- 纳入标准:异常的巴氏涂片检查或与HPV相关的疾病的随访,用胆囊镜指导的阴道活检.
主要成果:
- 组织学分布:41.6%的VaIN1,34.2%的VaIN2,24.2%的VaIN3.
- 对VaIN的专镜敏感度,特异性,PPV和NPV分别为56.3%,64.5%,69%和51.2%.
- 结肠镜检查的整体诊断准确率为59.7%,结肠镜检查和组织学等级之间的相关性较差.
结论:
- 结肠镜导向活检对于VaIN诊断和分级至关重要.
- 主要的结肠镜异常与高度的VaIN (HG-VaIN) 有中度的相关性.
- 一级结肠镜检测结果并不排除HG-VaIN,需要对所有异常的巴氏涂片进行活检.
相关概念视频
Histology of the Uterus
1.4K
The uterine wall consists of three histological layers: the perimetrium, myometrium, and endometrium. The outermost perimetrium is a thin, serous membrane connected with the broad ligament on the sides, which helps anchor the uterus in the pelvic cavity. The thickest layer, myometrium, is mainly made up of smooth muscle tissue bundles. Its contractions are vital in facilitating the expulsion of the uterine lining, fetus, and placenta during menstruation and childbirth.
The endometrium is the...
The endometrium is the...
1.4K
Classification of Epithelial Tissues: Overview
13.5K
Epithelial tissues are classified according to the shape of the cells and the number of cell layers formed. Cell shapes can be squamous (flattened and thin), cuboidal (square-like, as wide as it is tall), or columnar (rectangular, taller than it is wide). Additionally, the nucleus shape helps identify the type of epithelial cells. Squamous cells have flattened disc-shaped nuclei, cuboidal cells have spherical nuclei, and columnar cells have elongated nuclei.
Based on the number of cell layers,...
Based on the number of cell layers,...
13.5K
Classification of Epithelial Tissues: Stratified Epithelium
9.1K
Stratified epithelium consists of several stacked layers of cells. They provide the durability to withstand constant physical and chemical attacks. Stratified epithelium is named after the shape of the most apical layer of cells. Stratified squamous epithelium is the most common type found in the human body. In this tissue, the apical cells are squamous, whereas the basal layer contains either columnar or cuboidal cells. The basal cells divide to form new daughter cells, which gradually become...
9.1K
Classification of Epithelial Tissues: Glandular Epithelium
8.8K
The glandular epithelium is made of one or more epithelial cells modified to synthesize and secrete chemical substances. Glandular epithelia can be classified based on cell number. Unicellular glands have individual secretory cells scattered across the epithelial monolayer. In contrast, multicellular glands consist of a hollow tubular duct attached to the cluster of secretory cells located in the deep pockets.
Multicellular glands are formed during early development when epithelial budding...
Multicellular glands are formed during early development when epithelial budding...
8.8K


