夜间氧和与全因死亡率有关:一项基于社区的研究
Bin Yan1, Yang Gao2, Zhanqin Zhang3
1Department of Clinical Research Center, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China.
概括
夜间氧和 (SpO2) 监测可以预测一般人群中所有原因的死亡率. 改善夜间低氧症对于更好的健康结果至关重要.
科学领域:
- 心脏病学 心脏病学
- 睡眠医学 睡眠医学
- 公共卫生 公共卫生
背景情况:
- 观察性研究表明,单点氧和度 (SpO2) 测量与死亡率之间存在联系.
- 作为社区人口死亡率的预测因素,夜间SPO2水平尚未得到广泛研究.
研究的目的:
- 调查夜间SpO2水平与全因死亡率之间的关联.
- 确定夜间SPO2是否可以作为一般社区样本中死亡率的预测标记.
主要方法:
- 利用了睡眠心脏健康研究的数据,包括5086名参与者 (平均年龄63.8岁).
- 测量 SpO2 在总睡眠时间 (SpO2-TOTAL) 使用过夜在家中的多睡眠学.
- 采用多变量Cox比例危险分析来评估死亡风险.
主要成果:
- 在长达10.7年的随访期间,死亡人数为1110人 (22.7%).
- 经过调整后,平均SPO2-TOTAL与所有原因死亡率 (HR 0.93;P < .001) 有显著关联.
- 最大和最小的SpO2-TOTAL也预测了死亡率 (HRs分别为0.91和0.98;P =.001).
- 夜间低氧症与增加全因死亡率有显著的关联.
结论:
- 夜间的SpO2水平是一般人群所有原因死亡风险的重要指标.
- 监测夜间的SpO2和管理低氧症可能会改善健康结果.
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