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身高,自身免疫性甲状腺疾病和甲状腺癌:孟德尔的随机化研究
Areti Papadopoulou1, Bjørn O Åsvold2,3, Stephen Burgess4,5
1William Harvey Research Institute, Faculty of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom.
Thyroid : official journal of the American Thyroid Association
|September 29, 2023
概括
增加身高与自身免疫性甲状腺疾病 (AITD) 和甲状腺癌的风险更高有关. 这项研究没有发现反向因果关系,这表明身高可能会影响甲状腺健康.
科学领域:
- 遗传学和流行病学
- 内分泌学 在内分泌学.
- 癌症研究 癌症研究
背景情况:
- 流行病学研究表明,身高增加与甲状腺功能低下症和甲状腺癌风险增加之间存在相关性.
- 身高和甲状腺疾病之间的因果关系,包括自身免疫性甲状腺疾病 (AITD) 和甲状腺癌,需要进一步调查.
- 甲状腺功能低下症的主要原因是AITD,这使得它成为研究与身高相关的甲状腺关联的相关结果.
研究的目的:
- 调查基因预测的身高与AITD风险之间的潜在因果关系.
- 为了检查基因预测的身高和甲状腺癌的风险之间的因果关系.
- 评估AITD和成人身高之间的反向因果关系.
主要方法:
- 门德尔随机化 (MR) 分析利用来自大规模元分析的身高遗传变异.
- 针对AITD (30,234例) 和甲状腺癌 (3001例) 的全基因组关联研究总结统计数据被采用.
- 进行了双向MR,以探索潜在的反向因果关系.
主要成果:
- 基因预测高度的1-SD增加与AITD风险增加4%有关 (p=1.99E-03).
- 基因预测高度的1-SD增加与15%的甲状腺癌风险增加有关 (p=2.32E-04).
- 在AITD和成年人身高之间没有发现显著的因果关系.
结论:
- 遗传预测的身高与AITD和甲状腺癌的风险增加有关.
- 没有证据表明AITD会因果影响成人的身高.
- 这些发现突出了与身高相关的途径,作为理解AITD和甲状腺癌背后的机制的潜在目标.
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