与SARS-CoV-2相关的嗅觉丧失在临床上与其他病毒没有区别:一个多中心队列研究
M M Miyake1, F C P Valera2, R B Martins2
1Ribeiro Preto Medical School, University of Sao Paulo, Ribeiro Preto, SP, Brazil and Santa Casa de Sao Paulo School of Medical Sciences, Sao Paulo, SP, Brazil.
由于COVID-19或其他病毒引起的突然气味丧失也会产生类似的结果. 病毒载量和并发感染不会使患者的嗅觉恢复恶化.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 传染性疾病 传染性疾病
- 神经学 神经学
背景情况:
- 随着COVID-19大流行,人们对嗅觉损失的认识提高了,但其他呼吸道病毒也会导致这种症状.
- 了解SARS-CoV-2与其他病毒对气味的影响的差异至关重要.
研究的目的:
- 为了比较SARS-CoV-2和其他呼吸道病毒在患有突然气味丧失的患者中的患病率.
- 评估SARS-CoV-2病毒载量和并发感染对嗅觉症状的影响.
主要方法:
- 一项多中心前性队列研究涉及15家巴西医院的213名突然嗅觉丧失的患者.
- 收集的数据包括临床问卷,嗅觉测试 (CCCRC) 和PCR基病毒面板的鼻抽样在基线,30日和60天.
- 根据SARS-CoV-2测试结果和并发感染的存在,患者被分类.
主要成果:
- 188名患者检测出SARS-CoV-2阳性,其中65人同时感染;25人检测出SARS-CoV-2阴性.
- 两组SARS-CoV-2阳性和阴性组均在基线呈现客观解,没有显著差异.
- 到第60天,无论SARS-CoV-2状态或并发感染,在两组中都观察到显著的气味评分改善.
结论:
- 由于SARS-CoV-2和其他呼吸道病毒而引起的突然气味丧失呈现类似的情况,最初出现厌氧,并在60天内得到实质性的恢复.
- 既没有SARS-CoV-2病毒载量,也没有与其他呼吸道病毒的同时感染与较差的嗅觉结果相关.
- 这些发现表明,无论这种队列中的特定病毒病因学如何,嗅觉恢复的预后都是可比的.
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