三胞胎寒冷受体和空气流感知在慢性鼻炎中发生变化
C Migneault-Bouchard1, K Lagueux2, J W Hsieh3
1Department of Anatomy, Universite du Quebec a Trois-Rivieres (UQTR), Trois-Rivieres, QC, Canada.
慢性鼻炎 (CRS) 患者表现出鼻内三角管功能降低,可能与TRPM8受体表达的改变有关. 这影响了CRS中的空气流感知和嗅觉功能.
科学领域:
- 耳鼻喉科 耳鼻喉科 耳鼻喉科
- 神经科学是一个神经科学.
- 免疫学 免疫学 免疫学
背景情况:
- 慢性鼻炎 (CRS) 中的鼻腔阻塞通常归因于物理因素.
- 然而,一些CRS病例涉及由于鼻内三角系统功能改变而引起的感知阻塞,影响空气流感知.
- 这项研究调查了鼻内三角管功能和CRS之间的联系.
研究的目的:
- 评估鼻内三角体系统变化与慢性鼻炎之间的关联.
- 为了比较三角管功能,嗅觉功能和CRS患者的鼻腔通透性,偏差鼻腔隔膜 (DNS) 患者和健康对照.
主要方法:
- 未来病例控制研究涉及15名CRS患者,18名DNS患者和16名健康对照.
- 嗅觉功能通过Sniffin' Sticks进行评估;三角管功能通过使用欧卡利普托和 cinnamaldehyde的三角管侧面化任务 (TLT) 进行评估.
- 使用峰值鼻鼓动流和VAS测量鼻腔通透度;分析三角管受体 (TRPM8,TRPA1,TRPV1) 和炎症标志物的粘膜活检.
主要成果:
- 与DNS和健康对照人群相比,CRS患者的嗅觉功能和欧卡利普托的TLT得分明显较低.
- 在CRS患者中,鼻腔通透率显著降低,在DNS患者中主观降低.
- 与DNS患者相比,在CRS患者的粘膜活检中发现了较高水平的短TRPM8 (sTRPM8-18).
结论:
- 在患有慢性鼻炎的患者中,鼻内三角管功能明显下降.
- 这种减少可能归因于TRPM8受体的短异型的过度表达.
- 这些发现表明,一种新的机制有助于感知CRS中的鼻腔阻塞.
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