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催化中的范式转变:电中和光中介催化交叉合反应

Maximilian D Palkowitz¹, Megan A Emmanuel², Martins S Oderinde³

¹Small Molecule Drug Discovery, Bristol Myers Squibb, 250 Water Street, Cambridge, Massachusetts 02141, United States.

Accounts of chemical research

|September 29, 2023

概括

使用电催化和光催化,还氧化化学使新的催化交叉合反应成为可能. 这些方法为合成复杂的有机分子提供了温和的条件和高选择性.

科学领域:

有机化学有机化学
催化剂是一种催化剂.
降解氧化化学降解氧化化学

背景情况:

过渡金属催化交叉合反应对于合成药品,农业化学品和材料至关重要.
传统的方法通常依赖于催化和双电子过程.
反氧化化学为具有挑战性的键形成提供了替代的单电子通路.

研究的目的:

概述最近在光学和电化学介导催化交叉合方面的进展.
为了比较光化学和电化学策略的机械特征.
为应用这些氧化还原驱动交叉合反应提供一个用户指南.

主要方法:

使用光反氧催化剂来调节过渡金属的氧化状态.
在异质电极表面使用电催化剂进行氧化还原控制.
研究C-C,C-O,C-N和C-S键形成的催化交叉合.

主要成果:

光学和电化学驱动的交叉合在温和条件下进行,具有高化学选择性和功能组耐受性.
与热方法相比,这些方法扩大了交叉合反应的范围和普遍性.
催化,当与电化学和光化学合并时,使新的合成可能性成为可能.

结论:

首排过渡金属与电触媒和光触媒的整合代表了交叉合技术的范式转变.
了解光化学和电化学方法之间的微妙差异是它们有效应用的关键.
这些氧化还原驱动的方法是合成精细化学品和制药相关化合物的强大工具.

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