流感增加了宿主对非肺部侵入性Streptococcus pyogenes感染的易感性
Andrea L Herrera1, Rashaun Potts1, Victor C Huber1
1Division of Basic Biomedical Sciences, The Sanford School of Medicine of the University of South Dakota, Vermillion, SD, USA.
Virulence
|September 29, 2023
概括
流感病毒感染增加了侵袭性A型链球菌 (iGAS) 疾病的风险和严重程度. 这项研究表明病毒性肺炎增加了小鼠iGAS疾病的可能性和死亡率.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 传染性疾病 传染性疾病
背景情况:
- 侵袭性A组链球菌 (iGAS) 疾病,包括细菌病和毒性休克综合征,死亡率高.
- 流行病学数据表明,流感病毒感染与iGAS疾病发病率增加之间存在联系.
研究的目的:
- 在小鼠模型中,调查先前的呼吸道流感A病毒 (IAV) 感染是否会加剧随后的入侵性A群链球菌 (GAS) 感染.
- 确定病毒性肺炎对GAS传播和宿主免疫反应的影响.
主要方法:
- 建立了IAV-GAS超级感染的小鼠模型.
- 在IAV肺部感染后,小鼠在不同的时间点内内感染了GAS.
- 评估了发病率,死亡率,细菌传播和血清细胞因子水平.
主要成果:
- 呼吸道IAV感染显著增加了小鼠GAS诱导的发病率和死亡率.
- 死亡率的增加与GAS扩散到血液,脏和肺部的增加相关.
- 在血清中观察到高水平的促炎细胞因子 (IFN-γ,IL-12,TNF-α,MCP-1,IL-27).
结论:
- 之前的呼吸道流感病毒感染增加了对严重系统性IGAS疾病的易感性.
- 这种增加的风险是显而易见的,即使GAS感染不是主要是呼吸道.
- 这些发现强调了病毒和细菌呼吸道感染之间的关键相互作用.
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