围神经侵入的分类分层口腔腔状细胞癌预后
Nicholas Fung1, Cara M Fleseriu1, Randall J Harley1
1Department of Otolaryngology-Head and Neck Surgery, University of Pittsburgh, Pittsburgh, Pennsylvania, U.S.A.
The Laryngoscope
|September 29, 2023
概括
在口腔状细胞癌 (OCSCC) 中对周围神经侵入 (PNI) 进行分类可以提高预后准确性. 外瘤PNI显著增加复发风险和恶化存活率,建议对OCSCC患者进行精确的分期.
科学领域:
- 在瘤学瘤学.
- 病理学 病理学 病理学
- 手术瘤学手术瘤学
背景情况:
- 围神经侵入 (PNI) 是口腔状细胞癌 (OCSCC) 的关键预后因素.
- 当前的分期系统可能无法完全捕捉到PNI的预后影响.
- 精确的PNI分类可以提高OCSCC的预后解决方案.
研究的目的:
- 确定围神经侵入 (PNI) 的分类是否可以提高AJCC8口腔状细胞癌 (OCSCC) 阶段系统的预后准确度.
主要方法:
- 对158名接受初级手术切除的OCSCC患者的回顾性分析 (2019年1月至2021年6月).
- 瘤样本分为四个PNI组:阴性,内,周围和外.
- 卡普兰-梅尔,考克斯回归和日志等级测试评估了对无复发生存 (RFS) 和整体生存 (OS) 的预后影响.
主要成果:
- 在PNI分类中,RFS (p=0.007) 和OS (p=0.002) 均有显著的分层.
- 与PNI阴性相比,外门PNI显示复发风险增加4.5倍,生存状况恶化.
- 外周PNI与更糟糕的生存状况有关,而内PNI并没有显著改变RFS或生存状况.
结论:
- 将PNI分为额外门,外周和内门的子类别,为OCSCC提供了渐进的预后分层.
- 这项试点研究表明,OCSCC预后评估的详细PNI分类具有潜在的附加值.
相关概念视频
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