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相关概念视频

The Bone Matrix01:18

The Bone Matrix

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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脊椎外科手术中的细胞骨矩阵 - - 它们值得冒风险吗:系统性审查

Mark J Lambrechts1, Tariq Z Issa1, Aditya Mazmudar1

  • 1Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Global spine journal
|September 29, 2023
PubMed
概括

细胞骨基质 (CBM) 在脊柱手术中显示出高的融合率,但存在风险. 需要更多的研究来证实CBM在脊髓融合程序中的好处和安全性.

关键词:
细胞骨基质的细胞骨基质.并发症可能导致并发症.骨科生理学 骨科生理学伪关节炎是一种伪关节炎.脊柱融合是指脊柱的融合.

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科学领域:

  • 整形外科手术 整形外科手术
  • 生物材料科学 生物材料科学
  • 脊髓融合是指脊髓的融合.

背景情况:

  • 细胞骨基质 (CBM) 在脊髓融合程序中被用作骨生物学.
  • 在脊椎手术中CBM的安全性和有效性需要彻底评估.

研究的目的:

  • 进行有关脊柱融合期间CBM植入相关的并发症和结果的文献的系统审查.

主要方法:

  • 从PubMed数据库的创建到2023年1月31日进行了系统审查.
  • 报告脊髓融合中特定CBM产品的研究分析了不良事件,重新手术,方法和融合率.

主要成果:

  • 包括19项涉及7种CBM产品的研究. 融合率各不相同 (腰部:68% - 98.7%;宫:87% - 100%),放射学标准不一致.
  • 虽然一些研究没有报告任何不良事件,但有一项研究指出严重的结核病传播. 在14项研究中存在利益冲突.

结论:

  • 在脊椎手术中CBM的证据仅限于低级别的,非比较性研究,通常由行业资助.
  • 据报道,融合率很高,但严重的并发症,包括感染,是令人担忧的.
  • 需要进行进一步的大规模临床试验,以确定CBM在脊柱融合中的风险益处概况.