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脊椎外科手术中的细胞骨矩阵 - - 它们值得冒风险吗:系统性审查

Mark J Lambrechts¹, Tariq Z Issa¹, Aditya Mazmudar¹

¹Rothman Orthopaedic Institute at Thomas Jefferson University, Philadelphia, PA, USA.

Global spine journal

|September 29, 2023

概括

细胞骨基质 (CBM) 在脊柱手术中显示出高的融合率,但存在风险. 需要更多的研究来证实CBM在脊髓融合程序中的好处和安全性.

科学领域:

整形外科手术整形外科手术
生物材料科学生物材料科学
脊髓融合是指脊髓的融合.

背景情况:

细胞骨基质 (CBM) 在脊髓融合程序中被用作骨生物学.
在脊椎手术中CBM的安全性和有效性需要彻底评估.

研究的目的:

进行有关脊柱融合期间CBM植入相关的并发症和结果的文献的系统审查.

主要方法:

从PubMed数据库的创建到2023年1月31日进行了系统审查.
报告脊髓融合中特定CBM产品的研究分析了不良事件,重新手术,方法和融合率.

主要成果:

包括19项涉及7种CBM产品的研究. 融合率各不相同 (腰部:68% - 98.7%;宫:87% - 100%),放射学标准不一致.
虽然一些研究没有报告任何不良事件,但有一项研究指出严重的结核病传播. 在14项研究中存在利益冲突.

结论:

在脊椎手术中CBM的证据仅限于低级别的,非比较性研究,通常由行业资助.
据报道,融合率很高,但严重的并发症,包括感染,是令人担忧的.
需要进行进一步的大规模临床试验,以确定CBM在脊柱融合中的风险益处概况.

关键词:

细胞骨基质的细胞骨基质.并发症可能导致并发症.骨科生理学骨科生理学伪关节炎是一种伪关节炎.脊柱融合是指脊柱的融合.

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