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合成,表征和抗菌活性的素化银纳米粒子的合成,表征和抗菌活性

Jiu Ge¹, Mengting Li¹, Jiahui Fan¹

¹Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai, P.R. China.

Journal of biomaterials science. Polymer edition

|September 29, 2023

概括

素/银纳米粒子 (CS-AgNPs) 通过破坏细胞膜对抗耐药细菌表现出强大的抗菌活性. 更高度的奇托桑可提高疗效和生物相容性,为传统抗生素提供了有希望的替代品.

科学领域:

材料科学材料科学材料科学
纳米技术纳米技术
生物医学工程生物医学工程

背景情况:

细菌感染是一个主要的健康威胁,由日益增长的多药耐药菌株加剧.
现有的抗生素对抗耐药细菌的效果越来越差.
迫切需要新的抗菌剂来应对这些挑战.

研究的目的:

合成和表征/银纳米粒子 (CS-AgNPs) 复合物作为新型抗菌剂.
评估CS-AgNPs对常见细菌病原体的抗菌疗效.
评估CS-AgNPs作为抗生素替代品的生物相容性和潜力.

主要方法:

通过不同度的奇托合成四种类型的CS-AgNPs复合物.
描述CS-AgNP的大小,形态和表面电荷 (泽塔电位).
使用活/死染色和体外细胞毒性测定,对大肠杆菌和黄金杆菌的抗菌活性进行评估.

主要成果:

合成的CS-AgNP具有一致的球形形态 (约. 20纳米) 和正面电荷,不论基托桑的数量.
抗菌功效随着基托桑度的增加而增加,显著抑制了细菌增殖和膜损伤.
在实验室中,CS-AgNPs表现出广泛的抗菌活性和高生物相容性,特别是在基托负载较高的情况下.

结论:

CS-AgNPs是有效的抗菌剂,对大肠杆菌和金黄色杆菌都有强烈的活性.
增强的抗菌作用与奇托桑度和与细菌酸甘油层的相互作用有关.
在各种医疗应用中,CS-AgNPs代表了传统抗生素的一个有希望的,生物相容的替代品.

关键词:

银纳米颗粒银纳米粒子它具有抗菌活性,具有抗菌活性.细菌细菌细菌是一种细菌.基多酸盐的使用方法膜损伤会导致膜损伤.

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