在绝经前乳腺癌中基因表达特征的塔莫西芬预测值:来自随机SBII:2试验的数据

在绝经前乳腺癌中基因表达特征的塔莫西芬预测值:来自随机SBII:2试验的数据

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Christine Lundgren^1,2,3, Julia Tutzauer⁴, Sarah E Church⁵

¹Department of Oncology, Region Jönköping County, Jönköping, Sweden. christine.lundgren@rjl.se.

Breast cancer research : BCR

|September 29, 2023

概括

基因表达特征预测了在绝经前乳腺癌中他莫西芬治疗的有效性. FOXA1表达是一种有前途的生物标志物,而其他标志物,如ESR1和乳腺细胞,则具有预后价值.

科学领域:

在瘤学瘤学.
基因组学就是基因组学.
药物基因组学药物基因组学

背景情况:

基因表达 (GEX) 签名为乳腺癌提供预后见解.
对于他莫西芬治疗的GEX特征的预测价值在很大程度上仍未被探索.
这项研究研究了GEX特征在绝经前早期乳腺癌患者的预测和预后作用.

研究的目的:

评估各种基因表达特征的塔莫西芬预测值.
评估这些特征在患有早期乳腺癌的绝经前妇女的预后影响.
确定潜在的生物标志物,以指导他莫西芬治疗决策.

主要方法:

从437名绝经前妇女的瘤组织中提取的RNA,随机分配给他莫西芬或没有全身治疗.
使用NanoString乳腺癌360TM面板进行的基因表达特征分析.
卡普兰-梅尔估计和考克斯回归分析了GEX特征,无复发间隔 (RFi) 和整体存活率 (OS) 之间的关联,并进行了错误发现率调整.

主要成果:

在ER+/HER2-瘤中,低FOXA1表达预测了对RFi和OS的提升.
高ESR1,巨细胞和PGR表达与分子亚型的10年RFi和OS改进相关.
高BC扩散和低氧得分与RFi和OS的较差结果有关.

结论:

福克斯A1表达是一种潜在的预测生物标志物,用于特莫西芬在ER+/HER2-绝经前乳腺癌中的疗效.
包括BC增殖,缺氧,巨细胞,AR,ESR1和PGR在内的签名显示出预后价值.
这些发现表明,GEX签名可以在这个患者群体中为治疗策略和预后评估提供信息.

关键词:

基因表达签名基因表达签名预测性的预测性的在更年期前,更年期前.预测预测预测预测的时间.塔莫西芬 (Tamoxifen) 是一种

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