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相关概念视频

Circadian Rhythms and Gene Regulation02:19

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The biological clock is involved in many aspects of regulating complex physiology in all animals. It was in 1935 when German zoologists, Hans Kalmus and Erwin Bünning, discovered the existence of circadian rhythm in Drosophila melanogaster. However, the internal molecular mechanisms behind the circadian clock remained a mystery until 1984, when Jeffrey C. Hall, Michael Rosbash, and Michael W. Young discovered the expression of the Per gene oscillating over a 24-hour cycle. In subsequent...
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Circadian rhythms are cyclic changes that are crucial in plasma drug concentrations. Various standard circadian parameters, including core body temperature, heart rate, and other cardiovascular factors, directly impact disease states and the therapeutic response to drug therapy.
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The liver, an essential organ in the human body, performs over 200 vital functions that can be broadly categorized into metabolic, hematological, endocrine regulation, and bile production.
Metabolic Regulation:
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Cellular needs and conditions vary from cell to cell and change within individual cells over time. For example, the required enzymes and energetic demands of stomach cells are different from those of fat storage cells, skin cells, blood cells, and nerve cells. Furthermore, a digestive cell works much harder to process and break down nutrients during the time that closely follows a meal compared with many hours after a meal. As these cellular demands and conditions vary, so do the amounts and...
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The circadian—or biological—clock is an intrinsic, timekeeping, molecular mechanism that allows plants to coordinate physiological activities over 24-hour cycles called circadian rhythms. Photoperiodism is a collective term for the biological responses of plants to variations in the relative lengths of dark and light periods. The period of light-exposure is called the photoperiod.
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相关实验视频

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多omics分析揭示了由食时间塑造的节律性肝功能.

Rongfeng Huang1, Jianghui Chen1, Meiyu Zhou1

  • 1Department of Cardiovascular Medicine, Center for Circadian Metabolism and Cardiovascular Disease, Southwest Hospital, Army Medical University, Chongqing, China.

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概括
此摘要是机器生成的。

饮食时间塑造了肝脏蛋白质学和脂质学中的日常节奏,超越了基因表达. 营养物质的可用性将重置脂肪酸代谢的昼夜钟调节,影响PERIOD2酸化.

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科学领域:

  • 时间生物学 时间生物学
  • 代谢学 代谢学 代谢学
  • 分子生物学分子生物学

背景情况:

  • 翻译后修改 (PTMs) 将养模式与日常生物节奏联系起来.
  • 饮食时间对超越转录组的昼间节律的影响还不太清楚.

研究的目的:

  • 在不同食时间条件下,全面描述小鼠肝脏中蛋白质组,四个PTM和脂质组的日常节奏.
  • 为了研究饮食时间如何影响白天节律和分子通路.

主要方法:

  • 在小鼠肝脏中对蛋白质组,酸化,无处不在,糖化,N-糖化和脂质组进行系统的分析.
  • 日间/睡眠时间限制的养 (DRF) 和夜间/清醒时间限制的养 (NRF) 的比较.
  • 整合性欧米克斯分析以确定关键的监管机制.

主要成果:

  • 在蛋白质层,PTM层和脂质层观察到强大的日常节奏.
  • 酸化是对营养物质最有反应的PTM,而化是最没有反应的.
  • 饮食时间重置脂肪酸代谢的时钟调节,这是PERIOD2在Ser971 (PER2-pSer971) 的节奏酸化证明的.
  • 通过营养物质的可用性来激活PER2-pSer971,在体内得到证实.

结论:

  • 饮食时间显著地组织了肝脏蛋白质和脂质组中的白天节律.
  • 通过PER2酸化介导的脂肪酸代谢的循环节调节,是通过餐时间重置的关键目标.
  • 这项研究为了解肝脏对改变食计划的反应提供了全面的资源.