高血压盐水对经过穿透腹部创伤后损害控制腹腔切除术的影响
Lee Schmidt1,2, Lillian Kang1, Taylor Hudson1
1Department of Surgery, Division of Trauma, Acute and Critical Care Surgery, Duke University School of Medicine, Durham, NC, USA.
概括
在经过损伤控制腹腔切除术后穿透腹部损伤的患者中,高血压盐水 (HTS) 输液显著减少了关闭的时间,并增加了早期初级关闭率. 这种方法可以减少液体复苏量,但不会导致急性损伤或电解质失衡.
科学领域:
- 创伤外科 手术 创伤外科
- 手术重症监护手术重症监护
- 紧急医疗 紧急医疗
- 液体复苏 复苏 液体复苏 复苏
背景情况:
- 紧急腹腔切除术后无法实现初级带关闭 (PFC) 与不良结果有关,如囊形成,切口,腹腔内感染.
- 高压盐水 (HTS) 输液在改善早期PFC率和减少损伤控制腹腔切除术 (DCL) 患者关闭时间方面表现有前途.
- 在经过穿透腹部损伤后接受DCL的患者中,最佳的液体复苏策略至关重要.
研究的目的:
- 评估HTS输液在缩短关闭时间的疗效,在经历DCL后穿透腹部损伤的患者.
- 评估HTS对复苏所需的晶体体体积的影响.
- 确定HTS输液是否诱导临床相关的急性损伤 (AKI) 或电解质失调.
主要方法:
- 对经过DCL的透腹部损伤患者的回顾性分析 (2015年1月至2018年12月).
- 对接受3%HTS输液和接受同位素 (ISO) 液体进行复苏的患者进行比较.
- 主要结局:早期PFC率 (72小时内) 和PFC的时间. 二次结局:AKI,障碍,无呼吸器的日子和停留时间.
主要成果:
- 与ISO.com相比,HTS组的关闭平均时间 (36.37 vs. 59.05小时) 显著缩短,PFC率 (100% vs. 73%) 较高.
- 输入HTS导致24小时和48小时平均液体体积显著降低 (分别为5.2L和8.6L,1.3L和2.6L).
- 虽然HTS组的度峰值和变化较高,但在AKI发病率,电解质失调或其他次要结果方面没有显著的跨组差异.
结论:
- 在DCL患者的HTS输液中,透性腹部损伤有效地减少了关闭的时间,达到100%的早期PFC.
- HTS减少了复苏液体体积,但对功能或电解质平衡没有显著的不良影响.
- 对于这种患者群体来说,HTS代表了一种安全有效的流体管理策略,支持早期PFC.
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