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多环芳化合物的混合物与端粒长度之间的性别特异性关联

Xiaoyu Hou¹, Ruiying Li¹, Juan Wang¹

¹Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, 450001, Henan, People's Republic of China.

Environmental geochemistry and health

|September 29, 2023

概括

血中的多环芳 (PAH) 与相对端粒长度 (RTL) 有关. 暴露于10种PAH的混合物显示出与RTL的积极关联,特定的PAH如,[a]pyrene和[ghi]perylene是主要贡献者.

科学领域:

环境健康环境健康
毒理学毒理学毒理学
分子流行病学分子流行病学

背景情况:

多环芳 (PAHs) 的尿中代谢物与相对端粒长度 (RTL) 有关,但可能受性别的影响.
血母PAH提供了更直接的衡量人类暴露的方法,需要对它们与RTL的共同关联进行调查.
了解这些关联对于识别对健康不利影响的主要贡献者至关重要.

研究的目的:

在农村群体中探索血母PAHs和RTL之间的联合关联.
确定导致RTL变化的特定PAHs.
调查这些协会中潜在的性别特异性差异.

主要方法:

分析了来自河南农村队列的2577名参与者的队列.
血PAH水平使用气体染色学与双重质谱学相结合来量化.
相对端粒长度 (RTL) 通过定量聚合酶连锁反应来测量.
用通用线性模型和量子g计算来评估关联.

主要成果:

在单个PAH (男性BghiP;女性BaP,BghiP,流感) 和RTL之间观察到积极的关联.
10种PAH的混合物与两种性别的RTL积极相关,主要是由流感,BaP和BghiP驱动的.
发现了特定于性别的关联,其中的差异可能与吸烟和烟暴露有关.

结论:

暴露于10种PAH的混合物与不同性别的RTL积极相关.
烯,[a]烯和[ghi]烯是观察到的关联的关键贡献者.
性别特异性的影响可能受到环境暴露的影响,如烟草和烟,为控制PAH相关的衰老疾病提供了洞察力.

关键词:

多环芳香碳化合物多环芳香碳化合物量子的g-计算方式.相对的端粒长度相关的端粒长度农村人口农村人口.

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