在认知健康的老年人中,药物和道路测试的表现
David B Carr1,2, Kebede Beyene3, Jason Doherty2
1Department of Medicine, Washington University in St Louis, St Louis, Missouri.
JAMA network open
|September 29, 2023
概括
某些药物,包括抗抑郁药和镇静剂,增加了老年人驾驶能力受损的风险. 这项研究强调了关于驾驶安全的谨慎处方和患者咨询的必要性.
科学领域:
- 老年学是一门学科.
- 药理学 药理学是指药理学的学科.
- 交通安全 交通安全 交通安全
背景情况:
- 老年人越来越多地被处方给有潜在副作用的药物.
- 以前的研究表明,某些药物与增加机动车辆撞车风险之间存在联系.
研究的目的:
- 评估特定药物类别与健康老年人驾驶能力下降之间的关联.
- 识别与驾驶障碍相关的人口和医疗因素.
- 测试某些药物是否会随着时间的推移增加驾驶障碍的风险.
主要方法:
- 对198名65岁以上的认知健康成年人进行前性队列研究.
- 每年进行后续检查,包括标准化道路测试 (华盛顿大学道路测试).
- 分析药物使用情况 (抗抑郁药,镇静剂,NSAID等). 使用考克斯的比例危险模型.
主要成果:
- 抗抑郁药物,血清素 - 上腺素再吸收抑制剂,镇静剂 / 催眠药和NSAID与失败道路测试的风险增加有关.
- 降脂剂与较低的驾驶障碍风险有关.
- 对于抗胆固醇药或抗组胺剂,没有发现显著的关联.
结论:
- 特定的药物类别与老年人驾驶表现较差有关.
- 临床医生在给老年患者开处方时应考虑这些发现,并建议他们注意驾驶风险.
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