消除:基于PCR记录的宏观消除项目,用于系统召回奥地利的HCV-RNA阳性患者
Caroline Schwarz1,2,3, David Bauer1,2,3, Livia Dorn4
1Division of Gastroenterology and Hepatology, Department of Medicine III, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria.
Wiener klinische Wochenschrift
|September 29, 2023
概括
这项研究使用实验室记录确定了6006名患有潜在正在进行的C型肝炎病毒 (HCV) 病毒病的个人. 尽管面临挑战,但许多失去了跟踪成功与护理联系在一起,并开始抗病毒治疗以消除HCV.
科学领域:
- 肝病学 肝病学是一种肝病学.
- 病毒学 病毒学
- 公共卫生 公共卫生
背景情况:
- 针对特定的C型肝炎病毒 (HCV) 风险群体的微清除策略已经取得了成功.
- 使用现有实验室数据识别所有患有HCV病毒病的个体的宏观消除方法,可以推进全球HCV消除工作.
研究的目的:
- 通过实验室记录系统地识别患有病毒病的个体,以潜在消除HCV.
- 评估召回患者治疗的可行性和结果,这些患者的HCV-RNA PCR结果为阳性.
主要方法:
- 在奥地利东部的病毒学实验室,对2008-2020年HCV-RNA PCR结果进行了回顾性分析.
- 识别可检测的HCV-RNA的个体,然后系统召回治疗评估和持续病毒学反应 (SVR) 文档.
- 介绍来自8个参与中心的初步数据的中期报告.
主要成果:
- 在22682名测试人员中,6006人 (26.5%) 在最后一次PCR测试中检测到HCV-RNA.
- 与33.5%的被评估个体建立了联系,导致30.1%的治疗开始.
- 持续病毒学反应 (SVR) 在66.2%开始抗病毒治疗的人群中实现.
结论:
- 该项目成功地确定了大量可能患有持续性HCV病毒病的个体.
- 消除HCV的障碍包括不有效的联系数据和错过的治疗评估预约.
- 这项研究表明,有可能重新吸引那些失去了随访的HCV病毒病患者,将他们与基本护理和治疗联系起来.
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