慢性鼻炎患者的指示性肠道微生物群的改变
Michał Michalik1, Adrianna Podbielska-Kubera1, Anna Maria Basińska2
1MML Medical Center, Warsaw, Poland.
Immunity, inflammation and disease
|September 29, 2023
概括
慢性鼻炎患者表现出降低了有益的肠道细菌水平,例如Bifidobacterium和Faecalibacterium prausnitzii. 这些肠道微生物群失衡可能导致慢性鼻炎,这表明有针对性的益生菌和益生菌疗法的潜力.
科学领域:
- 微生物学 微生物学
- 免疫学 免疫学 免疫学
- 胃肠病学 胃肠病学
背景情况:
- 鼻微生物群受到各种因素的影响,抗菌剂显著破坏微生物平衡.
- 慢性鼻炎往往会持续,尽管有传统的治疗方法,如手术和抗生素.
- 肠道微生物群的不平衡被假定会导致鼻炎的慢性.
研究的目的:
- 为了确定与慢性鼻炎患者免疫相关的特定肠道指标细菌.
- 为了比较慢性鼻炎患者的细菌计数与慢性鼻炎 (CRS) 和并发症患者的细菌计数.
主要方法:
- 对慢性鼻炎患者的肠道指标细菌种群的分析.
- 慢性鼻炎患者 (G1) 与CRS和并发症患者 (G2) 之间的细菌水平的比较.
主要成果:
- 在G1的患者显示显著减少了Bifidobacterium spp. 和Faecalibacterium prausnitzii. 这是一个很好的例子.
- 大多数G1患者减少了Bifidobacterium和Akkermansia muciniphila,这对肠道健康和抗炎功能至关重要.
- G2患者表现出F.prausnitzii,Bifidobacterium spp.,A.muciniphila和Lactobacillus spp.的减少,有些人表现出真菌过度生长.
结论:
- 在慢性鼻炎患者中观察到特定肠道细菌 (Bifidobacterium,F.prausnitzii,A.muciniphila) 的水平降低.
- 肠道微生物群分析可以为慢性鼻炎的个性化益生菌和益生菌治疗提供信息.
- 准肠道微生物群可以提高慢性鼻炎患者的肠道健康和粘膜免疫力.
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